Development and application of health outcome descriptors facilitated decision-making in the production of practice guidelines

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dc.contributor.authorWiercioch, Wojtek
dc.contributor.authorNieuwlaat, Robby
dc.contributor.authorDahm, Philipp
dc.contributor.authorIorio, Alfonso
dc.contributor.authorMustafa, Reem A.
dc.contributor.authorNeumann, Ignacio
dc.contributor.authorRochwerg, Bram
dc.contributor.authorManja, Veena
dc.contributor.authorAlonso-Coello, Pablo
dc.contributor.authorOrtel, Thomas L.
dc.contributor.authorSantesso, Nancy
dc.contributor.authorVesely, Sara K.
dc.contributor.authorAkl, Elie A.
dc.contributor.authorSchuenemann, Holger J.
dc.contributor.authorZakai, Neil
dc.contributor.authorCuker, Adam
dc.contributor.authorLim, Wendy
dc.contributor.authorMonagle, Paul
dc.contributor.authorKunkle, Robert
dc.contributor.authorWitt, Daniel M.
dc.contributor.authorKahn, Susan R.
dc.contributor.authorMcLintock, Claire
dc.contributor.authorRezende, Suely M.
dc.contributor.authorZakai, Neil A.
dc.date.accessioned2025-01-20T22:06:53Z
dc.date.available2025-01-20T22:06:53Z
dc.date.issued2021
dc.description.abstractObjective: Stakeholders involved in developing recommendations need to have a common understanding of health outcomes and the perspective of affected individuals. In this paper we report on the development and application of health outcome descriptors (HODs) to inform decision-making by panels developing guideline recommendations.
dc.description.abstractStudy Design and Setting: Ten American Society of Hematology guideline panels addressing the management of venous thromboembolism developed HODs, rated their importance and health utility, applied them to prioritize outcomes, and to balance potential benefits and harms to formulate recommendations.
dc.description.abstractResults: It was feasible to involve 18 panelists in developing 127 HODs. There was high agreement (82%) across the ten panels about outcomes perceived as critical or important for decision-making. Panelists' utility ratings of the outcomes were strongly correlated with panelists' outcome importance ratings (Pearson's r =-0.88). HODs were incorporated into Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence-to-decision (EtD) frameworks to support a shared understanding of health outcomes in panel deliberations.
dc.description.abstractConclusion: HODs serve as a valuable tool to promote an explicit, common understanding of health outcomes during clinical guideline development and across different stakeholders. They are helpful across multiple steps of guideline development to facilitate panels' judgements, aiming to avoid variable implicit interpretations of health outcomes. (C) 2021 Elsevier Inc. All rights reserved.
dc.description.funderAmerican Society of Hematology
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jclinepi.2021.04.016
dc.identifier.eissn1878-5921
dc.identifier.issn0895-4356
dc.identifier.urihttps://doi.org/10.1016/j.jclinepi.2021.04.016
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94225
dc.identifier.wosidWOS:000704350400012
dc.language.isoen
dc.pagina.final127
dc.pagina.inicio115
dc.revistaJournal of clinical epidemiology
dc.rightsacceso restringido
dc.subjectClinical practice guidelines
dc.subjectHealth outcomes
dc.subjectClinical decision-making
dc.subjectHealth recommendations
dc.subjectGRADE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDevelopment and application of health outcome descriptors facilitated decision-making in the production of practice guidelines
dc.typeartículo
dc.volumen138
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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