Maternal obesity is associated with a sex-specific epigenetic programming in human neonatal monocytes
| dc.contributor.author | Vega-Tapia, Fabian | |
| dc.contributor.author | Artigas, Rocio | |
| dc.contributor.author | Hernandez, Cherie | |
| dc.contributor.author | Uauy, Ricardo | |
| dc.contributor.author | Casanello, Paola | |
| dc.contributor.author | Krause, Bernardo J. | |
| dc.contributor.author | Castro-Rodriguez, Jose A. | |
| dc.date.accessioned | 2025-01-23T19:46:58Z | |
| dc.date.available | 2025-01-23T19:46:58Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methylated CpGs were determined using an Infinium MethylationEPIC-BeadChip (850K). Results: No clustering of samples according to maternal BMI was observed, but sex-specific analysis revealed 71,728 differentially methylated CpGs in female neonates from women with obesity (p < 0.01). DAVID analysis showed increased methylation levels within genes involved in the innate immune response and inflammation. Conclusion: Maternal obesity induces, in a sex-specific manner, an epigenetic programming of monocytes that could contribute to disease later in life. | |
| dc.fuente.origen | WOS | |
| dc.identifier.doi | 10.2217/epi-2020-0098 | |
| dc.identifier.eissn | 1750-192X | |
| dc.identifier.issn | 1750-1911 | |
| dc.identifier.uri | https://doi.org/10.2217/epi-2020-0098 | |
| dc.identifier.uri | https://repositorio.uc.cl/handle/11534/100336 | |
| dc.identifier.wosid | WOS:000595571900001 | |
| dc.issue.numero | 22 | |
| dc.language.iso | en | |
| dc.pagina.final | 2018 | |
| dc.pagina.inicio | 1999 | |
| dc.revista | Epigenomics | |
| dc.rights | acceso restringido | |
| dc.subject | DNA methylation | |
| dc.subject | fetal programming | |
| dc.subject | maternal obesity | |
| dc.subject | monocytes | |
| dc.subject.ods | 05 Gender Equality | |
| dc.subject.ods | 03 Good Health and Well-being | |
| dc.subject.odspa | 05 Igualdad de género | |
| dc.subject.odspa | 03 Salud y bienestar | |
| dc.title | Maternal obesity is associated with a sex-specific epigenetic programming in human neonatal monocytes | |
| dc.type | artículo | |
| dc.volumen | 12 | |
| sipa.index | WOS | |
| sipa.trazabilidad | WOS;2025-01-12 |