Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects

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dc.contributor.authorWistuba, II
dc.contributor.authorBehrens, C
dc.contributor.authorMilchgrub, S
dc.contributor.authorVirmani, AK
dc.contributor.authorJagirdar, J
dc.contributor.authorThomas, B
dc.contributor.authorIoachim, HL
dc.contributor.authorLitzky, LA
dc.contributor.authorBrambilla, EM
dc.contributor.authorMinna, JD
dc.contributor.authorGazdar, AF
dc.date.accessioned2024-01-10T12:38:07Z
dc.date.available2024-01-10T12:38:07Z
dc.date.issued1998
dc.description.abstractContext.-Human immunodeficiency virus (HIV) infection has been associated with an increasing incidence of malignancy, and HIV-infected persons have an increased incidence of primary lung carcinoma compared with the general population,
dc.description.abstractObjective.-To investigate the molecular changes present in HIV-associated lung tumors and compare them with those present in lung carcinomas arising in HIV-indeterminate subjects ("sporadic tumors").
dc.description.abstractDesign.-Convenience sample.
dc.description.abstractSubjects.-Archival tissues from 11 HIV-positive persons and from 35 persons of indeterminate HIV status.
dc.description.abstractSetting.-University-based medical centers and affiliated hospitals.
dc.description.abstractMain Outcome Measures.-Analysis of frequency of loss of heterozygosity (LOH) and microsatellite alteration (MA) using polymerase chain reaction and 16 polymorphic microsatellite markers at 8 chromosomal regions frequently deleted in lung cancer. Presence of HIV and human papillomavirus (HPV) sequences.
dc.description.abstractResults.-The overall frequency of LOH at all chromosomal regions tested and the frequencies at most of the individual regions were similar in the 2 groups, Frequency of MA present in the HIV-associated tumors (0.18) was 6-fold higher than in sporadic tumors (0.03) (P<.001). At least 1 MA was present in 10 (91%) of 11 HIV-associated tumors vs 17 (48%) of 35 sporadic tumors (P=.02). Molecular changes were independent of tumor stage and gender. HIV and HPV sequences were not detected in the HIV-associated lung carcinomas.
dc.description.abstractConclusions.-Microsatellite alterations, which reflect widespread genomic instability, occur at greatly increased frequency in HIV-associated lung carcinomas, Although the mechanism underlying the development of increased MAs is unknown, it may play a crucial role in the development of many HIV-associated tumors.
dc.description.funderNCI NIH HHS
dc.description.funderNATIONAL CANCER INSTITUTE
dc.fechaingreso.objetodigital02-04-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1001/jama.279.19.1554
dc.identifier.issn0098-7484
dc.identifier.pubmedidMEDLINE:9605900
dc.identifier.urihttps://doi.org/10.1001/jama.279.19.1554
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76986
dc.identifier.wosidWOS:000073608100034
dc.information.autorucMedicina;Wistuba I;S/I;100278
dc.issue.numero19
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1559
dc.pagina.inicio1554
dc.publisherAMER MEDICAL ASSOC
dc.revistaJAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
dc.rightsacceso restringido
dc.subjectPOLYMERASE CHAIN-REACTION
dc.subjectIMMUNODEFICIENCY-VIRUS INFECTION
dc.subjectHUMAN PAPILLOMAVIRUS DNA
dc.subjectMICROSATELLITE INSTABILITY
dc.subjectMISMATCH REPAIR
dc.subjectCHEST RADIOGRAPHS
dc.subjectCT SCANS
dc.subjectCARCINOMA
dc.subjectLESIONS
dc.subjectGENE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleComparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects
dc.typeartículo
dc.volumen279
sipa.codpersvinculados100278
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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