Light-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with gold nanoclusters

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dc.article.number103046
dc.contributor.authorBejarano, Julian
dc.contributor.authorRojas, Aldo
dc.contributor.authorRamirez Sagredo, Andrea
dc.contributor.authorRiveros, Ana L.
dc.contributor.authorMorales Zavala, Francisco
dc.contributor.authorFlores, Yvo
dc.contributor.authorRiquelme, Jaime A.
dc.contributor.authorGuzman, Fanny
dc.contributor.authorAraya, Eyleen
dc.contributor.authorChiong, Mario
dc.contributor.authorOcaranza, María Paz
dc.contributor.authorMorales, Javier O.
dc.contributor.authorVillamizar Sarmiento, Maria Gabriela
dc.contributor.authorSanchez, Gina
dc.contributor.authorLavandero, Sergio
dc.contributor.authorKogan, Marcelo J.
dc.date.accessioned2024-06-15T08:00:13Z
dc.date.available2024-06-15T08:00:13Z
dc.date.issued2020
dc.description.abstractAngiotensin-(1-9), a component of the non-canonical renin-angiotensin system, has a short half-life in blood. This peptide has shown to prevent and/or attenuate hypertension and cardiovascular remodeling. A controlled release of angiotensin-(1-9) is needed for its delivery to the heart. Our aim was to develop a drug delivery system for angiotensin-(1-9). Thermosensitive liposomes (LipoTherm) were prepared with gold nanoclusters (LipoThermAuNC) to increase the stability and reach a temporal and spatial control of angiotensin-(1-9) release. Encapsulation efficiencies of nearly 50% were achieved in LipoTherm, reaching a total angiotensin-(1-9) loading of around 180 mu M. This angiotensin-(1-9)-loaded LipoTherm sized around 100 nm and exhibited a phase transition temperature of 43.C. AuNC were grown on LipoTherm and the new hybrid nanosystem showed energy absorption in the near-infrared (NIR) wavelength range. By NIR laser irradiation, a controlled release of angiotensin-(1-9) was achieved from the LipoTherm-AuNC nanosystem. These nanosystems did not show any cytotoxic effect on cultured cardiomyocytes. Biological activity of angiotensin-(1-9) released from the LipoTherm-AuNCbased nanosystem was confirmed using an ex vivo Langendorff heart model.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo (ANID), Chile
dc.description.funderPuente Pontificia Universidad Catolica de Chile
dc.description.funderFondecyt
dc.description.funderBayer AG
dc.description.funderAnillo
dc.description.funderFondecyt Postdoctoral Fellowship
dc.description.funderFONDEQUIP
dc.format.extent14 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jconrel.2020.11.002
dc.identifier.eissn1873-4995
dc.identifier.issn0168-3659
dc.identifier.pubmedidMEDLINE:33160006
dc.identifier.scopusidSCOPUS_ID:85182725436
dc.identifier.urihttps://doi.org/10.1016/j.jconrel.2020.11.002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86791
dc.identifier.wosidWOS:000600791600062
dc.information.autorucEscuela de Medicina; Ocaranza, María Paz; 0000-0002-4915-6378; 1001254
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final872
dc.pagina.inicio859
dc.revistaJOURNAL OF CONTROLLED RELEASE
dc.rightsacceso restringido
dc.subjectAngiotensin-(1-9)
dc.subjectCardioprotection
dc.subjectCardiovascular diseases
dc.subjectThermosensitive liposomes
dc.subjectNanoparticles
dc.subjectGrowth Factor I
dc.subjectConverting-Enzyme
dc.subjectDrug-delivery
dc.subjectCardiovascular-disease
dc.subjectTemperature
dc.subjectAbsorption
dc.subjectTransition
dc.subjectPressure
dc.subjectRat
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLight-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with gold nanoclusters
dc.typeartículo
dc.volumen328
sipa.codpersvinculados1001254
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-06-2024
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