Reduced microbial diversity of the nasopharyngeal microbiome in household contacts with latent tuberculosis infection
dc.catalogador | vzp | |
dc.contributor.author | Ruiz-Tagle Seguel, Cinthya Grace | |
dc.contributor.author | Ugalde, Juan A. | |
dc.contributor.author | Naves Pichuante, Rodrigo Antonio | |
dc.contributor.author | Araos, Rafael | |
dc.contributor.author | Garcia Canete, Patricia Del Carmen | |
dc.contributor.author | Balcells Marty, Maria Elvira | |
dc.date.accessioned | 2023-11-10T16:15:08Z | |
dc.date.available | 2023-11-10T16:15:08Z | |
dc.date.issued | 2023 | |
dc.description.abstract | The upper respiratory tract is an obliged pathway for respiratory pathogens and a healthy microbiota may support the host's mucosal immunity preventing infection. We analyzed the nasopharyngeal microbiome in tuberculosis household contacts (HHCs) and its association with latent tuberculosis infection (TBI). A prospective cohort of HHCs was established and latent TBI status was assessed by serial interferon-& gamma; release assay (IGRA). Nasopharyngeal swabs collected at baseline were processed for 16S rRNA gene sequencing. The 82 participants included in the analysis were classified as: (a) non-TBI [IGRA negative at baseline and follow-up, no active TB (n = 31)], (b) pre-TBI [IGRA negative at baseline but converted to IGRA positive or developed active TB at follow-up (n = 16)], and (c) TBI [IGRA positive at enrollment (n = 35)]. Predominant phyla were Actinobacteriota, Proteobacteria, Firmicutes and Bacteroidota. TBI group had a lower alpha diversity compared to non-TBI (p(adj) = 0.04) and pre-TBI (p(adj) = 0.04). Only TBI and non-TBI had beta diversity differences (p(adj) = 0.035). Core microbiomes' had unique genera, and genus showed differential abundance among groups. HHCs with established latent TBI showed reduced nasopharyngeal microbial diversity with distinctive taxonomical composition. Whether a pre-existing microbiome feature favors, are a consequence, or protects against Mycobacterium tuberculosis needs further investigation. | |
dc.description.funder | ANID/CONICYT FONDECYT | |
dc.fechaingreso.objetodigital | 2023-11-07 | |
dc.format.extent | 12 páginas | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.1038/s41598-023-34052-8 | |
dc.identifier.eissn | 20452322 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://doi.org/10.1038/s41598-023-34052-8 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/75278 | |
dc.identifier.wosid | WOS:001022552200001 | |
dc.information.autoruc | Escuela de Medicina; Ruiz-tagle Seguel Cinthya Grace; 0000-0002-4712-3302; 1098594 | |
dc.information.autoruc | Escuela de Medicina; Naves Pichuante Rodrigo Antonio; 0000-0002-1203-3593; 200771 | |
dc.information.autoruc | Escuela de Medicina; Garcia Canete Patricia Del Carmen; 0000-0002-5983-2392; 73909 | |
dc.information.autoruc | Escuela de Medicina; Balcells Marty Maria Elvira; 0000-0002-7223-9665; 7462 | |
dc.issue.numero | 1 | |
dc.language.iso | en | |
dc.nota.acceso | Contenido parcial | |
dc.publisher | NATURE PORTFOLIO | |
dc.revista | Scientific Reports | |
dc.rights | acceso restringido | |
dc.subject | Humans | |
dc.subject | Interferon-gamma Release Tests | |
dc.subject | Latent Tuberculosis | |
dc.subject | Microbiota | |
dc.subject | Mycobacterium tuberculosis | |
dc.subject | Prospective Studies | |
dc.subject | RNA, Ribosomal, 16S | |
dc.subject | Tuberculosis | |
dc.subject.ddc | 610 | |
dc.subject.dewey | Medicina y salud | es_ES |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | Reduced microbial diversity of the nasopharyngeal microbiome in household contacts with latent tuberculosis infection | |
dc.type | artículo | |
dc.volumen | 13 | |
sipa.codpersvinculados | 1098594 | |
sipa.codpersvinculados | 200771 | |
sipa.codpersvinculados | 73909 | |
sipa.codpersvinculados | 7462 |
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