Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients

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dc.contributor.authorCandia, Enzo
dc.contributor.authorDiaz Jimenez, David
dc.contributor.authorLangjahr, Patricia
dc.contributor.authorNunez, Lucia E.
dc.contributor.authorde la Fuente, Marjorie
dc.contributor.authorFarfan, Nancy
dc.contributor.authorLopez Kostner, Francisco
dc.contributor.authorAbedrapo, Mario
dc.contributor.authorAlvarez Lobos, Manuel
dc.contributor.authorPinedo, George
dc.contributor.authorBeltran, Caroll J.
dc.contributor.authorGonzalez, Carlos
dc.contributor.authorGonzalez, Maria Julieta
dc.contributor.authorQuera, Rodrigo
dc.contributor.authorHermoso, Marcela A.
dc.date.accessioned2024-01-10T13:49:24Z
dc.date.available2024-01-10T13:49:24Z
dc.date.issued2012
dc.description.abstractToll-like receptor 2 (TLR2) is a type I pattern recognition receptor that has been shown to participate in intestinal homeostasis. Its increased expression in the lamina propria has been associated with the pathogenesis in inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD). Recently, soluble TLR2 (sTLR2) variants have been shown to counteract inflammatory responses driven by the cognate receptor. Despite the evident roles of TLR2 in intestinal immunity, no study has elucidated the production and cellular source of sTLR2 in IBD. Furthermore, an increase in the population of activated macrophages expressing TLR2 that infiltrates the intestine in IBD has been reported. We aimed first to assess the production of the sTLR2 by UC and CD organ culture biopsies and lamina propria mononuclear cells (LPMCs) as well as the levels of sTLR2 in serum, and then characterize the cell population from lamina propria producing the soluble protein.
dc.description.abstractMucosa explants, LPMCs and serum were obtained from UC, CD patients and control subjects. The level of sTLR2 was higher in conditioned media from organ culture biopsies and LPMCs from UC patients in comparison to CD and controls. Moreover, an inverse correlation between the content of intestinal and serum sTLR2 levels was observed in UC patients. Additionally, when characterizing the cellular source of the increased sTLR2 by LPMCs from UC patients, an increase in TLR2(+)/CD33(+) cell population was found. Also, these cells expressed CX3CR1, which was related to the increased levels of intestinal FKN in UC patients, suggesting that a higher proportion of TLR2(+) mononuclear cells infiltrate the lamina propria. The increased production of sTLR2 suggests that a differential regulating factor of the innate immune system is present in the intestinal mucosa of UC patients. (C) 2011 Elsevier GmbH. All rights reserved.
dc.description.funderScience and Technology Foundation of Chile (FONDECYT)
dc.description.funderAcademic Direction of Las Condes; Clinic (DA-CLC)
dc.fechaingreso.objetodigital26-03-2024
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.imbio.2011.10.023
dc.identifier.issn0171-2985
dc.identifier.pubmedidMEDLINE:22101184
dc.identifier.urihttps://doi.org/10.1016/j.imbio.2011.10.023
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79447
dc.identifier.wosidWOS:000306346900009
dc.information.autorucMedicina;Alvarez M ;S/I;6131
dc.information.autorucMedicina;Pinedo G ;S/I;1002552
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final642
dc.pagina.inicio634
dc.publisherELSEVIER GMBH
dc.revistaIMMUNOBIOLOGY
dc.rightsacceso restringido
dc.subjectToll-like receptor 2
dc.subjectUlcerative colitis
dc.subjectInflammatory bowel diseases
dc.subjectMonocytes
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectTOLL-LIKE RECEPTOR-2
dc.subjectINTESTINAL MACROPHAGES
dc.subjectCROHNS-DISEASE
dc.subjectCOLONIC-MUCOSA
dc.subjectEXPRESSION
dc.subjectPOLYMORPHISM
dc.subjectRECOGNITION
dc.subjectRECRUITMENT
dc.subjectINDUCTION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIncreased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients
dc.typeartículo
dc.volumen217
sipa.codpersvinculados6131
sipa.codpersvinculados1002552
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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