The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas-Another Model of Disrupted Human-Pathogen Co-Evolution

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dc.catalogadoryvc
dc.contributor.authorCorvalán Rodríguez, Alejandro
dc.contributor.authorRuedlinger, Jenny
dc.contributor.authorMayo, Tomás de
dc.contributor.authorPolakovicova, Iva
dc.contributor.authorGonzález-Hormázabal, Patricio
dc.contributor.authorAguayo, Francisco
dc.date.accessioned2024-01-19T14:06:44Z
dc.date.available2024-01-19T14:06:44Z
dc.date.issued2019
dc.description.abstractEpstein-Barr virus (EBV) is an etiological agent for gastric cancer with significant worldwide variations. Molecular characterizations of EBV have shown phylogeographical variations among healthy populations and in EBV-associated diseases, articularly the cosegregated BamHI-I fragment and XhoI restriction site of exon 1 of the LMP-1 gene. In the Americas, both cosegregated variants are present in EBV carriers, which aligns with the history of Asian and European human migration to this continent. Furthermore, novel recombinant variants have been found, reflecting the genetic makeup of this continent. However, in the case of EBV-associated gastric cancer (EBV-associated GC), the cosegregated European BamHI-“i” fragment and XhoI restriction site strain prevails. Thus, we propose that a disrupted coevolution between viral phylogeographical strains and mixed human ancestry in the Americas might explain the high prevalence of this particular gastric cancer subtype. This cosegregated region contains two relevant transcripts for EBV-associated GC, the BARF-1 and miR-BARTs. Thus, genome-wide association studies (GWAS) or targeted sequencing of both transcripts may be required to clarify their role as a potential source of this disrupted coevolution.
dc.fechaingreso.objetodigital2024-04-18
dc.fuente.origenORCID
dc.identifier.doi10.3390/CANCERS11020217
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80631
dc.identifier.urihttps://doi.org/10.3390/cancers11020217
dc.information.autorucEscuela de medicina ; Corvalán, Alejandro H. ; 0000-0001-5492-3853 ; 63885
dc.information.autorucEscuela de medicina ; Polakovicova, Iva ; S/I ; 1018034
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaCancers
dc.rightsacceso abierto
dc.subjectGastric cancer
dc.subjectEpstein-Barr Virus
dc.subjectHuman ancestry
dc.subjectViral phylogeograph
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleThe Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas-Another Model of Disrupted Human-Pathogen Co-Evolution
dc.typeartículo
dc.volumen11
sipa.codpersvinculados63885
sipa.codpersvinculados1018034
sipa.trazabilidadORCID;2024-01-08
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