HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort

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dc.contributor.authorChambers, Stephen T.
dc.contributor.authorMurdoch, David
dc.contributor.authorMorris, Arthur
dc.contributor.authorHolland, David
dc.contributor.authorPappas, Paul
dc.contributor.authorAlmela, Manel
dc.contributor.authorFernandez-Hidalgo, Nuria
dc.contributor.authorAlmirante, Benito
dc.contributor.authorBouza, Emilio
dc.contributor.authorForno, Davide
dc.contributor.authordel Rio, Ana
dc.contributor.authorHannan, Margaret M.
dc.contributor.authorHarkness, John
dc.contributor.authorKanafani, Zeina A.
dc.contributor.authorLalani, Tahaniyat
dc.contributor.authorLang, Selwyn
dc.contributor.authorRaymond, Nigel
dc.contributor.authorRead, Kerry
dc.contributor.authorVinogradova, Tatiana
dc.contributor.authorWoods, Christopher W.
dc.contributor.authorWray, Dannah
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorChu, Vivian H.
dc.contributor.authorClara, Liliana
dc.contributor.authorSanchez, Marisa
dc.contributor.authorNacinovich, Francisco
dc.contributor.authorFernandez Oses, Pablo
dc.contributor.authorRonderos, Ricardo
dc.contributor.authorSucari, Adriana
dc.contributor.authorThierer, Jorge
dc.contributor.authorCasabe, Jose
dc.contributor.authorCortes, Claudia
dc.contributor.authorAltclas, Javier
dc.contributor.authorKogan, Silvia
dc.contributor.authorSpelman, Denis
dc.contributor.authorAthan, Eugene
dc.contributor.authorHarris, Owen
dc.contributor.authorKennedy, Karina
dc.contributor.authorTan, Ren
dc.contributor.authorGordon, David
dc.contributor.authorPapanicolas, Lito
dc.contributor.authorEisen, Damon
dc.contributor.authorGrigg, Leeanne
dc.contributor.authorStreet, Alan
dc.contributor.authorKorman, Tony
dc.contributor.authorKotsanas, Despina
dc.contributor.authorDever, Robyn
dc.contributor.authorJones, Phillip
dc.contributor.authorKonecny, Pam
dc.contributor.authorLawrence, Richard
dc.contributor.authorRees, David
dc.contributor.authorRyan, Suzanne
dc.contributor.authorFeneley, Michael P.
dc.contributor.authorHarkness, John
dc.contributor.authorJones, Phillip
dc.contributor.authorRyan, Suzanne
dc.contributor.authorJones, Phillip
dc.contributor.authorRyan, Suzanne
dc.contributor.authorJones, Phillip
dc.contributor.authorPost, Jeffrey
dc.contributor.authorReinbott, Porl
dc.contributor.authorRyan, Suzanne
dc.contributor.authorGattringer, Rainer
dc.contributor.authorWiesbauer, Franz
dc.contributor.authorAndrade, Adriana Ribas
dc.contributor.authorPassos de Brito, Ana Claudia
dc.contributor.authorGuimaraes, Armenio Costa
dc.contributor.authorGrinberg, Max
dc.contributor.authorMansur, Alfredo Jose
dc.contributor.authorSiciliano, Rinaldo Focaccia
dc.contributor.authorVarejao Strabelli, Tania Mara
dc.contributor.authorCampos Vieira, Marcelo Luiz
dc.contributor.authorde Medeiros Tranchesi, Regina Aparecida
dc.contributor.authorPaiva, Marcelo Goulart
dc.contributor.authorFortes, Claudio Querido
dc.contributor.authorRamos, Auristela de Oliveira
dc.contributor.authorFerraiuoli, Giovanna
dc.contributor.authorGolebiovski, Wilma
dc.contributor.authorLamas, Cristiane
dc.contributor.authorSantos, Marisa
dc.contributor.authorWeksler, Clara
dc.contributor.authorKarlowsky, James A.
dc.contributor.authorKeynan, Yoav
dc.contributor.authorMorris, Andrew M.
dc.contributor.authorRubinstein, Ethan
dc.contributor.authorJones, Sandra Braun
dc.contributor.authorGarcia, Patricia
dc.contributor.authorCereceda, M.
dc.contributor.authorFica, Alberto
dc.contributor.authorMella, Rodrigo Montagna
dc.contributor.authorBarsic, Bruno
dc.contributor.authorBukovski, Suzana
dc.contributor.authorKrajinovic, Vladimir
dc.contributor.authorPangercic, Ana
dc.contributor.authorRudez, Igor
dc.contributor.authorVincelj, Josip
dc.contributor.authorFreiberger, Tomas
dc.contributor.authorPol, Jiri
dc.contributor.authorZaloudikova, Barbora
dc.contributor.authorAshour, Zainab
dc.contributor.authorEl Kholy, Amani
dc.contributor.authorMishaal, Marwa
dc.contributor.authorRizk, Hussien
dc.contributor.authorAissa, Neijla
dc.contributor.authorAlauzet, Corentine
dc.contributor.authorAlla, Francois
dc.contributor.authorCampagnac, Catherine
dc.contributor.authorDoco-Lecompte, Thanh
dc.contributor.authorSelton-Suty, Christine
dc.contributor.authorCasalta, Jean-Paul
dc.contributor.authorFournier, Pierre-Edouard
dc.contributor.authorHabib, Gilbert
dc.contributor.authorRaoult, Didier
dc.contributor.authorThuny, Franck
dc.contributor.authorDelahaye, Francois
dc.contributor.authorDelahaye, Armelle
dc.contributor.authorVandenesch, Francois
dc.contributor.authorDonal, Erwan
dc.contributor.authorDonnio, Pierre Yves
dc.contributor.authorMichelet, Christian
dc.contributor.authorRevest, Matthieu
dc.contributor.authorTattevin, Pierre
dc.contributor.authorViolette, Jeremie
dc.contributor.authorChevalier, Florent
dc.contributor.authorJeu, Antoine
dc.contributor.authorDan
dc.contributor.authorRusinaru
dc.contributor.authorSorel, Claire
dc.contributor.authorTribouilloy, Christophe
dc.contributor.authorBernard, Yvette
dc.contributor.authorChirouze, Catherine
dc.contributor.authorHoen, Bruno
dc.contributor.authorLeroy, Joel
dc.contributor.authorPlesiat, Patrick
dc.contributor.authorNaber, Christoph
dc.contributor.authorNeuerburg, Carl
dc.contributor.authorMazaheri, Bahram
dc.contributor.authorNaber, Christoph
dc.contributor.authorNeuerburg, Carl
dc.contributor.authorAthanasia, Sofia
dc.contributor.authorGiannitsioti, Efthymia
dc.contributor.authorMylona, Elena
dc.contributor.authorPaniara, Olga
dc.contributor.authorPapanicolaou, Konstantinos
dc.contributor.authorPyros, John
dc.contributor.authorSkoutelis, Athanasios
dc.contributor.authorSharma, Gautam
dc.contributor.authorFrancis, Johnson
dc.contributor.authorNair, Lathi
dc.contributor.authorThomas, Vinod
dc.contributor.authorVenugopal, Krishnan
dc.contributor.authorHannan, Margaret
dc.contributor.authorHurley, John
dc.contributor.authorGilon, Dan
dc.contributor.authorIsrael, Sarah
dc.contributor.authorKorem, Maya
dc.contributor.authorStrahilevitz, Jacob
dc.contributor.authorRubinstein, Ethan
dc.contributor.authorStrahilevitz, Jacob
dc.contributor.authorTripodi, Marie Francoise
dc.contributor.authorCasillo, Roberta
dc.contributor.authorCuccurullo, Susanna
dc.contributor.authorDialetto, Giovanni
dc.contributor.authorDurante-Mangoni, Emanuele
dc.contributor.authorIrene, Mattucci
dc.contributor.authorRagone, Enrico
dc.contributor.authorUtili, Riccardo
dc.contributor.authorCecchi, Enrico
dc.contributor.authorDe Rosa, Francesco
dc.contributor.authorForno, Davide
dc.contributor.authorImazio, Massimo
dc.contributor.authorTrinchero, Rita
dc.contributor.authorTebini, Alessandro
dc.contributor.authorGrossi, Paolo
dc.contributor.authorLattanzio, Mariangela
dc.contributor.authorToniolo, Antonio
dc.contributor.authorGoglio, Antonio
dc.contributor.authorRaglio, Annibale
dc.contributor.authorRavasio, Veronica
dc.contributor.authorRizzi, Marco
dc.contributor.authorSuter, Fredy
dc.contributor.authorCarosi, Giampiero
dc.contributor.authorMagri, Silvia
dc.contributor.authorSignorini, Liana
dc.contributor.authorBaban, Tania
dc.contributor.authorKanafani, Zeina
dc.contributor.authorKanj, Souha S.
dc.contributor.authorSfeir, Jad
dc.contributor.authorYasmine, Mohamad
dc.contributor.authorAbidin, Imran
dc.contributor.authorTamin, Syahidah Syed
dc.contributor.authorMartinez, Eduardo Rivera
dc.contributor.authorNieto, Gabriel Israel Soto
dc.contributor.authorvan der Meer, Jan T. M.
dc.contributor.authorChambers, Stephen
dc.contributor.authorHolland, David
dc.contributor.authorMorris, Arthur
dc.contributor.authorRaymond, Nigel
dc.contributor.authorRead, Kerry
dc.contributor.authorMurdoch, David R.
dc.contributor.authorDragulescu, Stefan
dc.contributor.authorIonac, Adina
dc.contributor.authorMornos, Cristian
dc.contributor.authorButkevich, O. M.
dc.contributor.authorChipigina, Natalia
dc.contributor.authorKirill, Ozerecky
dc.contributor.authorVadim, Kulichenko
dc.contributor.authorVinogradova, Tatiana
dc.contributor.authorEdathodu, Jameela
dc.contributor.authorHalim, Magid
dc.contributor.authorLum, Luh-Nah
dc.contributor.authorTan, Ru-San
dc.contributor.authorLejko-Zupanc, Tatjana
dc.contributor.authorLogar, Mateja
dc.contributor.authorMueller-Premru, Manica
dc.contributor.authorCommerford, Patrick
dc.contributor.authorCommerford, Anita
dc.contributor.authorDeetlefs, Eduan
dc.contributor.authorHansa, Cass
dc.contributor.authorNtsekhe, Mpiko
dc.contributor.authorAlmela, Manuel
dc.contributor.authorArmero, Yolanda
dc.contributor.authorAzqueta, Manuel
dc.contributor.authorCastaneda, Ximena
dc.contributor.authorCervera, Carlos
dc.contributor.authordel Rio, Ana
dc.contributor.authorFalces, Carlos
dc.contributor.authorGarcia-de-la-Maria, Cristina
dc.contributor.authorFita, Guillermina
dc.contributor.authorGatell, Jose M.
dc.contributor.authorMarco, Francesc
dc.contributor.authorMestres, Carlos A.
dc.contributor.authorMiro, Jose M.
dc.contributor.authorMoreno, Asuncion
dc.contributor.authorNinot, Salvador
dc.contributor.authorPare, Carlos
dc.contributor.authorPericas, Joan
dc.contributor.authorRamirez, Jose
dc.contributor.authorRovira, Irene
dc.contributor.authorSitges, Marta
dc.contributor.authorAnguera, Ignasi
dc.contributor.authorFont, Bernat
dc.contributor.authorGuma, Joan Raimon
dc.contributor.authorBermejo, Javier
dc.contributor.authorBouza, Emilio
dc.contributor.authorGarcia Fernandez, Miguel Angel
dc.contributor.authorGonzalez-Ramallo, Victor
dc.contributor.authorMarin, Mercedes
dc.contributor.authorMunoz, Patricia
dc.contributor.authorPedromingo, Miguel
dc.contributor.authorRoda, Jorge
dc.contributor.authorRodriguez-Creixems, Marta
dc.contributor.authorSolis, Jorge
dc.contributor.authorAlmirante, Benito
dc.contributor.authorFernandez-Hidalgo, Nuria
dc.contributor.authorTornos, Pilar
dc.contributor.authorde Alarcon, Aristides
dc.contributor.authorParra, Ricardo
dc.contributor.authorAlestig, Eric
dc.contributor.authorJohansson, Magnus
dc.contributor.authorOlaison, Lars
dc.contributor.authorSnygg-Martin, Ulrika
dc.contributor.authorPachirat, Orathai
dc.contributor.authorPachirat, Pimchitra
dc.contributor.authorPussadhamma, Burabha
dc.contributor.authorSenthong, Vichai
dc.contributor.authorCasey, Anna
dc.contributor.authorElliott, Tom
dc.contributor.authorLambert, Peter
dc.contributor.authorWatkin, Richard
dc.contributor.authorEyton, Christina
dc.contributor.authorKlein, John L.
dc.contributor.authorBradley, Suzanne
dc.contributor.authorKauffman, Carol
dc.contributor.authorBedimo, Roger
dc.contributor.authorChu, Vivian H.
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorCrowley, Anna Lisa
dc.contributor.authorDouglas, Pamela
dc.contributor.authorDrew, Laura
dc.contributor.authorFowler, Vance G.
dc.contributor.authorHolland, Thomas
dc.contributor.authorLalani, Tahaniyat
dc.contributor.authorMudrick, Daniel
dc.contributor.authorSamad, Zaniab
dc.contributor.authorSexton, Daniel
dc.contributor.authorStryjewski, Martin
dc.contributor.authorWang, Andrew
dc.contributor.authorWoods, Christopher W.
dc.contributor.authorLerakis, Stamatios
dc.contributor.authorCantey, Robert
dc.contributor.authorSteed, Lisa
dc.contributor.authorWray, Dannah
dc.contributor.authorDickerman, Stuart A.
dc.contributor.authorBonilla, Hector
dc.contributor.authorDiPersio, Joseph
dc.contributor.authorSalstrom, Sara-Jane
dc.contributor.authorBaddley, John
dc.contributor.authorPatel, Mukesh
dc.contributor.authorPeterson, Gail
dc.contributor.authorStancoven, Amy
dc.contributor.authorAfonso, Luis
dc.contributor.authorKulman, Theresa
dc.contributor.authorLevine, Donald
dc.contributor.authorRybak, Michael
dc.contributor.authorCabell, Christopher H.
dc.contributor.authorBaloch, Khaula
dc.contributor.authorChu, Vivian H.
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorDixon, Christy C.
dc.contributor.authorFowler, Vance G.
dc.contributor.authorHarding, Tina
dc.contributor.authorJones-Richmond, Marian
dc.contributor.authorPappas, Paul
dc.contributor.authorPark, Lawrence P.
dc.contributor.authorRedick, Thomas
dc.contributor.authorStafford, Judy
dc.contributor.authorAnstrom, Kevin
dc.contributor.authorAthan, Eugene
dc.contributor.authorBayer, Arnold S.
dc.contributor.authorCabell, Christopher H.
dc.contributor.authorChu, Vivian H.
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorFowler, Vance G.
dc.contributor.authorHoen, Bruno
dc.contributor.authorKarchmer, A. W.
dc.contributor.authorMiro, Jose M.
dc.contributor.authorMurdoch, David R.
dc.contributor.authorSexton, Daniel J.
dc.contributor.authorWang, Andrew
dc.contributor.authorBayer, Arnold S.
dc.contributor.authorCabell, Christopher H.
dc.contributor.authorChu, Vivian
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorDurack, David T.
dc.contributor.authorPhil, D.
dc.contributor.authorEykyn, Susannah
dc.contributor.authorFowler, Vance G.
dc.contributor.authorHoen, Bruno
dc.contributor.authorMiro, Jose M.
dc.contributor.authorMoreillon, Phillipe
dc.contributor.authorOlaison, Lars
dc.contributor.authorRaoult, Didier
dc.contributor.authorRubinstein, Ethan
dc.contributor.authorSexton, Daniel J.
dc.date.accessioned2025-01-24T00:04:10Z
dc.date.available2025-01-24T00:04:10Z
dc.date.issued2013
dc.description.abstractThe HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p < 0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p < 0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p < 0.01) and younger age (OR 0.62; CI 0.49-0.90; p < 0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p < 0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0063181
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0063181
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101786
dc.identifier.wosidWOS:000319107900026
dc.issue.numero5
dc.language.isoen
dc.revistaPlos one
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort
dc.typeartículo
dc.volumen8
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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