Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing

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dc.article.number761
dc.catalogadorjlo
dc.contributor.authorSarabia-Vallejos, Mauricio A.
dc.contributor.authorRomero De la Fuente, Scarlett
dc.contributor.authorCohn-Inostroza, Nicolás A.
dc.contributor.authorTerraza Inostroza, Claudio Alberto
dc.contributor.authorRodriguez-Hernandez, Juan
dc.contributor.authorGonzález-Henríquez, Carmen M.
dc.date.accessioned2025-03-19T16:11:15Z
dc.date.available2025-03-19T16:11:15Z
dc.date.issued2024
dc.description.abstractThe preparation of sophisticated hierarchically structured and cytocompatible hydrogel scaffolds is presented. For this purpose, a photosensitive resin was developed, printability was evaluated, and the optimal conditions for 3D printing were investigated. The design and fabrication by additive manufacturing of tailor-made porous scaffolds were combined with the formation of surface wrinkled micropatterns. This enabled the combination of micrometer-sized channels (100–200 microns) with microstructured wrinkled surfaces (1–3 μm wavelength). The internal pore structure was found to play a critical role in the mechanical properties. More precisely, the TPMS structure with a zero local curvature appears to be an excellent candidate for maintaining its mechanical resistance to compression stress, thus retaining its structural integrity upon large uniaxial deformations up to 70%. Finally, the washing conditions selected enabled us to produce noncytotoxic materials, as evidenced by experiments using AlamarBlue to follow the metabolic activity of the cells.
dc.description.funderUTEM
dc.description.funderCSIC
dc.description.funderFONDECYT
dc.description.funderFONDECYT
dc.description.funderANID-Chile
dc.description.funderMinisterio de Ciencia, Innovación y Universidades
dc.description.funderMinisterio de Ciencia, Innovación y Universidades
dc.description.funderFONDEF IDeA I+D
dc.fechaingreso.objetodigital2025-03-19
dc.format.extent19 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.3390/gels10120761
dc.identifier.issn2310-2861
dc.identifier.scopusidSCOPUS_ID:85213334119
dc.identifier.urihttps://doi.org/10.3390/gels10120761
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102818
dc.information.autorucEscuela de Química; Terraza Inostroza, Claudio Alberto; 0000-0002-6326-8771; 1001668
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaGels
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject3D porous scaffolds
dc.subjectStereolithography
dc.subjectWrinkled nonplanar surfaces
dc.subject.ddc620
dc.subject.deweyIngenieríaes_ES
dc.titleDevelopment of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing
dc.typeartículo
dc.volumen10
sipa.codpersvinculados1001668
sipa.trazabilidadSCOPUS;2025-01-05
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