Copy number polymorphism of the salivary amylase gene: Implications in human nutrition research

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dc.catalogadorjlo
dc.contributor.authorSantos Martín, José Luis
dc.contributor.authorSaus, E.
dc.contributor.authorSmalley Meylan, Susan Valerie
dc.contributor.authorCataldo Bascuñan, Luis Rodrigo
dc.contributor.authorAlberti Reus, Gigliola Loredana
dc.contributor.authorParada, J.
dc.contributor.authorGratacòs, M.
dc.contributor.authorEstivill, X.
dc.date.accessioned2024-01-22T14:20:12Z
dc.date.available2024-01-22T14:20:12Z
dc.date.issued2012
dc.description.abstractThe salivary alpha-amylase is a calcium-binding enzyme that initiates starch digestion in the oral cavity. The alpha-amylase genes are located in a cluster on the chromosome that includes salivary amylase genes (AMY1), two pancreatic alpha-amylase genes (AMY2A and AMY2B) and a related pseudogene. The AMY1 genes show extensive copy number variation which is directly proportional to the salivary alpha-amylase content in saliva. The alpha-amylase amount in saliva is also influenced by other factors, such as hydration status, psychosocial stress level, and short-term dietary habits. It has been shown that the average copy number of AMY1 gene is higher in populations that evolved under high-starch diets versus low-starch diets, reflecting an intense positive selection imposed by diet on amylase copy number during evolution. In this context, a number of different aspects can be considered in evaluating the possible impact of copy number variation of the AMY1 gene on nutrition research, such as issues related to human diet gene evolution, action on starch digestion, effect on glycemic response after starch consumption, modulation of the action of alpha-amylases inhibitors, effect on taste perception and satiety, influence on psychosocial stress and relation to oral health. Copyright (C) 2012 S. Karger AG, Basel
dc.description.funderOtro
dc.fuente.origenHistorial Académico
dc.identifier.issn1661-6499
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80867
dc.identifier.wosidWOS:000311764800001
dc.information.autorucEscuela de Medicina; Santos Martín, José Luis; 0000-0003-2895-0369; 1005923
dc.information.autorucFacultad de Ciencias Biológicas; Smalley Meylan, Susan Valerie; S/I; 143948
dc.information.autorucEscuela de Medicina; Cataldo Bascuñan, Luis Rodrigo; 0000-0003-1225-414X; 1015508
dc.information.autorucEscuela de Medicina; Alberti Reus, Gigliola Loredana; 0000-0002-8540-1326; 167316
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final131
dc.pagina.inicio117
dc.revistaJournal of Nutrigenetics and Nutrigenomics
dc.rightsacceso restringido
dc.subjectAmylase
dc.subjectCopy number variation
dc.subjectSaliva
dc.subjectStarch
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCopy number polymorphism of the salivary amylase gene: Implications in human nutrition research
dc.typeartículo de revisión
dc.volumen5
sipa.codpersvinculados1005923
sipa.codpersvinculados143948
sipa.codpersvinculados1015508
sipa.codpersvinculados167316
sipa.trazabilidadHistorial Académico;09-07-2021
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