Methodology for predicting oxygen transport on an intravenous membrane oxygenator combining computational and analytical models

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dc.contributor.authorGuzman, AM
dc.contributor.authorEscobar, RA
dc.contributor.authorAmon, CH
dc.date.accessioned2024-01-10T12:40:21Z
dc.date.available2024-01-10T12:40:21Z
dc.date.issued2005
dc.description.abstractA computational methodology for accurately predicting flow and oxygen-transport characteristics and performance of an intravenous membrane oxygenator (IMO) device is developed, tested, and validated. This methodology uses extensive numerical simulations of three-dimensional computational models to determine flow-mixing characteristics and oxygen-transfer performance, and analytical models to indirectly validate numerical predictions with experimental data, using both blood and water as working fluids. Direct numerical simulations for IMO stationary and pulsating balloons predict flow field and oxygen transport performance in response to changes in the device length, number of fibers, and balloon pulsation frequency. Multifiber models are used to investigate interfiber interference and length effects for a stationary balloon whereas a single fiber model is used to analyze the effect of balloon pulsations on velocity and oxygen concentration fields and to evaluate oxygen transfer rates. An analytical lumped model is developed and validated by comparing its numerical predictions with experimental data. Numerical results demonstrate that oxygen transfer rates for a stationary balloon regime decrease with increasing number of fibers, independent of the fluid type. The oxygen transfer rate ratio obtained with blood and water is approximately two. Balloon pulsations show an effective and enhanced flow mixing, with time-dependent recirculating flows around the fibers regions which induce higher oxygen transfer rates. The mass transfer rates increase approximately 100% and 80%, with water and blood, respectively, compared with stationary balloon operation. Calculations with combinations of frequency, number of fibers, fiber length and diameter, and inlet volumetric flow rates, agree well with the reported experimental results, and provide a solid comparative base for analysis, predictions, and comparisons with numerical and experimental data.
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent14 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1115/1.2073669
dc.identifier.eissn1528-8951
dc.identifier.issn0148-0731
dc.identifier.pubmedidMEDLINE:16502655
dc.identifier.urihttps://doi.org/10.1115/1.2073669
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77300
dc.identifier.wosidWOS:000234259600010
dc.information.autorucIngeniería;Escobar R;S/I;158663
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1140
dc.pagina.inicio1127
dc.publisherASME
dc.revistaJOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
dc.rightsacceso restringido
dc.subjectHOLLOW-FIBER MEMBRANES
dc.subjectMATHEMATICAL-MODEL
dc.subjectCLINICAL-TRIALS
dc.subjectTRANSFER RATES
dc.subjectGAS-EXCHANGE
dc.subjectDESIGN
dc.subjectCHAOS
dc.subjectVIVO
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMethodology for predicting oxygen transport on an intravenous membrane oxygenator combining computational and analytical models
dc.typeartículo
dc.volumen127
sipa.codpersvinculados158663
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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