Estimation of the plasma-effect-site equilibration rate constant (k(e0)) of rocuronium by the time of maximum effect: a comparison with non-parametric and parametric approaches

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dc.contributor.authorCortinez, L. I.
dc.contributor.authorNazar, C.
dc.contributor.authorMunoz, H. R.
dc.date.accessioned2024-01-10T12:05:17Z
dc.date.available2024-01-10T12:05:17Z
dc.date.issued2007
dc.description.abstractBackground. The first order plasma-effect-site equilibration rate constant (k(e0)) links the pharmacokinetics (PK) and pharmacodynamics (PD) of a given drug. For the calculation of the k(e0), one method uses a single point of the response curve corresponding to the time to peak effect of a drug (t(peak)); however, it has not been validated. This study compares the k(e0) calculated with the method of tpeak and the k(e0) calculated with traditional non-parametric and parametric methods.
dc.description.abstractMethods. Fifteen adult patients receiving total intravenous anaesthesia (TIVA) were studied. All patients were monitored with an NMT Monitor 221 (GE Healthcare, Helsinki, Finland) to obtain the evoked compound EMG of the adductor pollicis to a train-of-four stimuli at 10 s intervals. During TIVA, rocuronium 0.15 mg kg(-1) was given i.v. as a bolus, and the neuromuscular response was recorded until recovery from block. Using the tpeak and the complete response curve, k(e0) of rocuronium was calculated with the three methods using the predicted plasma concentrations of rocuronium from a PK model. Values of k(e0) are median (range).
dc.description.abstractResults. The k(e0)s obtained were 0.19 min-1 (0.09-0.72) with the 't(peak)' method, 0.20 min(-1) (0.14-0.44) with the non-parametric method, and 0.19 min(-1) (0.11-0.38) [typical value (range)] with the parametric method (NS).
dc.description.abstractConclusions. If the tpeak can be adequately estimated from the data, the 't(peak) method' is a valid alternative to traditional methods to calculate the k(e0).
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/bja/aem212
dc.identifier.eissn1471-6771
dc.identifier.issn0007-0912
dc.identifier.pubmedidMEDLINE:17681967
dc.identifier.urihttps://doi.org/10.1093/bja/aem212
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75982
dc.identifier.wosidWOS:000250674600014
dc.information.autorucMedicina;Cortinez L;S/I;79356
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final685
dc.pagina.inicio679
dc.publisherELSEVIER SCI LTD
dc.revistaBRITISH JOURNAL OF ANAESTHESIA
dc.rightsacceso restringido
dc.subjectneuromuscular block, rocuronium
dc.subjectpharmacokinetics
dc.subjectpharmacology, rocuronium
dc.subjectPHARMACODYNAMIC MODEL
dc.subjectCONTROLLED INFUSION
dc.subjectBISPECTRAL INDEX
dc.subjectPHARMACOKINETICS
dc.subjectPROPOFOL
dc.titleEstimation of the plasma-effect-site equilibration rate constant (k(e0)) of rocuronium by the time of maximum effect: a comparison with non-parametric and parametric approaches
dc.typeartículo
dc.volumen99
sipa.codpersvinculados79356
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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