Optogenetic Suppression of Lateral Septum Somatostatin Neurons Enhances Hippocampus Cholinergic Theta Oscillations and Local Synchrony

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dc.contributor.authorEspinosa, Nelson
dc.contributor.authorAlonso, Alejandra
dc.contributor.authorCaneo, Mauricio
dc.contributor.authorMoran, Constanza
dc.contributor.authorFuentealba, Pablo
dc.date.accessioned2025-01-20T20:19:00Z
dc.date.available2025-01-20T20:19:00Z
dc.date.issued2023
dc.description.abstractThe septal complex regulates both motivated and innate behaviors, chiefly by the action of its diverse population of long-range projection neurons. A small population of somatostatin-expressing GABAergic cells in the lateral septum projects deep into subcortical regions, yet on its way it also targets neighboring medial septum neurons that profusely innervate cortical targets by ascending synaptic pathways. Here, we used optogenetic stimulation and extracellular recordings in acutely anesthetized transgenic mice to show that lateral septum somatostatin neurons can disinhibit the cholinergic septo-hippocampal pathway, thus enhancing the amplitude and synchrony of theta oscillations while depressing sharp-wave ripple episodes in the dorsal hippocampus. These results suggest that septal somatostatin cells can recruit ascending cholinergic pathways to promote hippocampal theta oscillations.
dc.fuente.origenWOS
dc.identifier.doi10.3390/brainsci13010001
dc.identifier.eissn2076-3425
dc.identifier.urihttps://doi.org/10.3390/brainsci13010001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92497
dc.identifier.wosidWOS:000917007700001
dc.issue.numero1
dc.language.isoen
dc.revistaBrain sciences
dc.rightsacceso restringido
dc.subjectoptogenetics
dc.subjectsomatostatin neurons
dc.subjecttheta oscillations
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOptogenetic Suppression of Lateral Septum Somatostatin Neurons Enhances Hippocampus Cholinergic Theta Oscillations and Local Synchrony
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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