Hybrid molecules based on 1,3,5-triazine as potential therapeutics: A focused review

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dc.catalogadoryvc
dc.contributor.authorPrasher, P.
dc.contributor.authorSharma, M.
dc.contributor.authorAljabali, Alaa A. A.
dc.contributor.authorGupta, G.
dc.contributor.authorNegi, P.
dc.contributor.authorKapoor, D. N.
dc.contributor.authorSingh, I.
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorAndreoli Pinto, T. de J.
dc.contributor.authorWebba da Silva, M.
dc.contributor.authorBakshi, H.
dc.contributor.authorChellappan, D. K.
dc.contributor.authorTambuwala, M. M.
dc.contributor.authorDua, K.
dc.date.accessioned2023-08-28T14:54:57Z
dc.date.available2023-08-28T14:54:57Z
dc.date.issued2020
dc.description.abstractMajority of the representative drugs customarily interact with multiple targets manifesting unintended side effects. In addition, drug resistance and over expression of the cellular efflux-pumps render certain classes of drugs ineffective. With only a few innovative formulations in development, it is necessary to identify pharmacophores and novel strategies for creating new drugs. The conjugation of dissimilar pharmacophoric moieties to design hybrid molecules with an attractive therapeutic profile is an emerging paradigm in the contemporary drug development regime. The recent decade witnessed the remarkable biological potential of 1,3,5-triazine framework in the development of various chemotherapeutics. The appending of the 1,3,5-triazine nucleus to biologically relevant moieties has delivered exciting results. The present review focuses on 1,3,5-triazine based hybrid molecules in the development of pharmaceuticals.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2023-08-28
dc.fuente.origenHistorial Académico
dc.identifier.citationPrashe, P.; Sharma, M.; Aljabali, Alaa A. A. et al. (2020). Hybrid molecules based on 1,3,5-triazine as potential therapeutics: A focused review. Drug Development Research. 2020;(21704):1-1.
dc.identifier.doi10.1002/ddr.21704
dc.identifier.issn0272-4391
dc.identifier.pubmedidMEDLINE_ID: 32579723
dc.identifier.urihttps://doi.org/10.1002/ddr.21704
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74512
dc.identifier.wosidWOS:000542433500001
dc.information.autorucEscuela de Química ; Zacconi, Flavia C. M. ; 0000-0002-3676-0453 ; 1011127
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final858
dc.pagina.inicio837
dc.revistaDrug Development Research
dc.rightsacceso restringido
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHybrid molecules based on 1,3,5-triazine as potential therapeutics: A focused review
dc.typeartículo de revisión
dc.volumen81
sipa.codpersvinculados1011127
sipa.indexWoS
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2023-08-20
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