Contribution of resident memory CD8+ T cells to protective immunity against respiratory syncytial virus and their impact on vaccine design

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dc.catalogadordfo
dc.contributor.authorRetamal Díaz, Angello
dc.contributor.authorCovián, Camila
dc.contributor.authorPacheco, Gaspar A.
dc.contributor.authorCastiglione Matamala, Angelo T.
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-01-29T15:21:48Z
dc.date.available2024-01-29T15:21:48Z
dc.date.issued2019
dc.description.abstractWorldwide, human respiratory syncytial virus (RSV) is the most common etiological agent for acute lower respiratory tract infections (ALRI). RSV-ALRI is the major cause of hospital admissions in young children, and it can cause in-hospital deaths in children younger than six months old. Therefore, RSV remains one of the pathogens deemed most important for the generation of a vaccine. On the other hand, the effectiveness of a vaccine depends on the development of immunological memory against the pathogenic agent of interest. This memory is achieved by long-lived memory T cells, based on the establishment of an effective immune response to viral infections when subsequent exposures to the pathogen take place. Memory T cells can be classified into three subsets according to their expression of lymphoid homing receptors: central memory cells (T-CM), effector memory cells (T-EM) and resident memory T cells (T-RM). The latter subset consists of cells that are permanently found in non-lymphoid tissues and are capable of recognizing antigens and mounting an effective immune response at those sites. T-RM cells activate both innate and adaptive immune responses, thus establishing a robust and rapid response characterized by the production of large amounts of effector molecules. T-RM cells can also recognize antigenically unrelated pathogens and trigger an innate-like alarm with the recruitment of other immune cells. It is noteworthy that this rapid and effective immune response induced by T-RM cells make these cells an interesting aim in the design of vaccination strategies in order to establish T-RM cell populations to prevent respiratory infectious diseases. Here, we discuss the biogenesis of T-RM cells, their contribution to the resolution of respiratory viral infections and the induction of T-RM cells, which should be considered for the rational design of new vaccines against RSV.
dc.description.funderVRAID (ex DIPUC)
dc.fechaingreso.objetodigital2025-03-14
dc.fuente.origenHistorial Académico
dc.identifier.citationRetamal Diaz Angello Ricardo, Bueno Ramirez Susan Marcela, Gonzalez Munoz Pablo Alberto, Kalergis Parra Alexis Mikes. Contribution of resident memory CD8+ T cells to protective immunity against respiratory syncytial virus and their impact on vaccine design. 2019;8(3):1-17.
dc.identifier.doi10.3390/pathogens8030147
dc.identifier.issn2076-0817
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81002
dc.identifier.wosidWOS:000488003600024
dc.information.autorucFacultad de Ciencias Biológicas; Retamal Diaz Angello Ricardo; 0000-0002-8840-1911; 225150
dc.information.autorucFacultad de Ciencias Biológicas; Pacheco Ruidiaz Gaspar Andres; S/I; 1047198
dc.information.autorucFacultad de Ciencias Biológicas; Castiglione Matamala Angelo Tomas; ; 1027831
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramirez Susan Marcela; 0000-0002-7551-8088; 113541
dc.information.autorucEscuela de Medicina; Kalergis Parra Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.revistaPathogens
dc.rightsacceso abierto
dc.subjectHuman respiratory syncytial virus
dc.subjectHuman orthopneumovirus
dc.subjectRespiratory infection
dc.subjectResident memory T cells
dc.subjectVaccine development
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleContribution of resident memory CD8+ T cells to protective immunity against respiratory syncytial virus and their impact on vaccine design
dc.typeartículo
dc.volumen8
sipa.codpersvinculados225150
sipa.codpersvinculados1047198
sipa.codpersvinculados1027831
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.trazabilidadHistorial Académico;09-07-2021
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