Relationship between <i>Helicobacter pylori</i> virulence factors and regulatory cytokines as predictors of clinical outcome

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dc.contributor.authorSerrano, Carolina
dc.contributor.authorDiaz, Maria Ines
dc.contributor.authorValdivia, Alejandra
dc.contributor.authorGodoy, Alex
dc.contributor.authorPena, Alfredo
dc.contributor.authorRollan, Antonio
dc.contributor.authorKirberg, Arturo
dc.contributor.authorHebel, Eduardo
dc.contributor.authorFierro, Jaqueline
dc.contributor.authorKlapp, Gabriela
dc.contributor.authorVenegas, Alejandro
dc.contributor.authorHarris, Paul R.
dc.date.accessioned2025-01-21T01:05:35Z
dc.date.available2025-01-21T01:05:35Z
dc.date.issued2007
dc.description.abstractHelicobacter pylori infection is highly prevalent in Chile (73%). Usually a minority of infected patients develops complications such as ulcers and gastric cancer that have been associated with the presence of virulence factors (cagA, vacA) and host T helper response (Th1/Th2). Our aim was to evaluate the relationship between strain virulence and host immune response, using a multiple regression approach for the development of a model based on data collected from H. pylori infected patients in Chile. We analyzed levels of selected cytokines determined by ELISA (interleukin (IL)-12, IL-10, interferon (IFN)-gamma and IL-4) and the presence of cagA and vacA alleles polymorphisms determined by PCR in antral biopsies of 41 patients referred to endoscopy. By multiple regression analysis we established a correlation between bacterial and host factors using clinical outcome (gastritis and duodenal ulcer) as dependent variables. The selected model was described by: clinical outcome = 0.867491 (cagA) + 0.0131847 (IL-12/IL-10) + 0.0103503 (IFN-gamma/IL-4) and it was able to explain over 90% of clinical outcomes observations (R-2=96.4). This model considers that clinical outcomes are better explained by the interaction of host immune factors and strain virulence as a complex and interdependent mechanism. (c) 2007 Elsevier Masson SAS. All rights reserved.
dc.description.funderNIDDK NIH HHS
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.micinf.2006.12.012
dc.identifier.eissn1769-714X
dc.identifier.issn1286-4579
dc.identifier.urihttps://doi.org/10.1016/j.micinf.2006.12.012
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95963
dc.identifier.wosidWOS:000245959800002
dc.issue.numero4
dc.language.isoen
dc.pagina.final434
dc.pagina.inicio428
dc.revistaMicrobes and infection
dc.rightsacceso restringido
dc.subjectHelicobacter pylori
dc.subjectvirulence factors
dc.subjectcytokines
dc.subjectgastroduodenal ulcer
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRelationship between <i>Helicobacter pylori</i> virulence factors and regulatory cytokines as predictors of clinical outcome
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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