Immunoregulatory Properties of Heme Oxygenase-1

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dc.catalogadorpau
dc.contributor.authorBlancou, Philippe
dc.contributor.authorTardif, Virginie
dc.contributor.authorSimon, Thomas
dc.contributor.authorRémy, Séverine
dc.contributor.authorCarreño, Leandro
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorAnegon, Ignacio
dc.date.accessioned2024-03-07T18:57:17Z
dc.date.available2024-03-07T18:57:17Z
dc.date.issued2011
dc.description.abstractHeme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by other stimuli, including agents involved in oxidative stress and proinflammatory cytokines as well as several anti-inflammatory stimuli. A growing body of evidence points toward the capacity of this molecule to inhibit immune reactions and the pivotal role of HO-1 in inflammatory diseases. We will first review the physiological role of HO-1 as determined by the analysis of HO-1-deficient individuals. This will be followed by an examination of the effect of HO-1 within immunopathological contexts such as immune disorders (autoimmunity and allergy) or infections. A section will be devoted to the use of an HO-1 inducer as an immunosuppressive molecule in transplantation. Finally, we will review the molecular basis of HO-1 actions on different immune cells.
dc.fuente.origenORCID
dc.identifier.doi10.1007/978-1-60761-869-0_18
dc.identifier.urihttps://doi.org/10.1007/978-1-60761-869-0_18
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84294
dc.identifier.wosidWOS:000283520000018
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoContenido parcial
dc.relation.ispartofSuppression and Regulation of Immune Responses. Methods in Molecular Biology, vol 677. Humana Press, Totowa, NJ, 2010, XVIII, 473 páginas.
dc.rightsacceso restringido
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImmunoregulatory Properties of Heme Oxygenase-1
dc.typecapítulo de libro
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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