High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis

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dc.contributor.authorBlanco, Rances
dc.contributor.authorCarrillo-Beltran, Diego
dc.contributor.authorCorvalan, Alejandro H.
dc.contributor.authorAguayo, Francisco
dc.date.accessioned2025-01-20T22:03:23Z
dc.date.available2025-01-20T22:03:23Z
dc.date.issued2021
dc.description.abstractSimple Summary A subset of carcinomas that arise in the head and neck region show a viral etiology. In fact, a subgroup of oropharyngeal cancers are caused by some types of human papillomavirus (HPV), so-called high-risk (HR)-HPVs, whereas undifferentiated nasopharyngeal carcinomas are etiologically related to Epstein-Barr virus (EBV). However, studies have reported the presence of both HR-HPV and EBV in some types of head and neck cancers. In this review, we discuss the potential contribution and role of HR-HPV/EBV coinfection in head and neck carcinogenesis, as well as the mechanisms that are potentially involved. In addition, HR-HPV/EBV interaction models are proposed. High-risk human papillomaviruses (HR-HPVs) and Epstein-Barr virus (EBV) are recognized oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). HR-HPVs are etiologically associated with a subset of oropharyngeal carcinomas (OPCs), whereas EBV is a recognized etiological agent of undifferentiated nasopharyngeal carcinomas (NPCs). In this review, we address epidemiological and mechanistic evidence regarding a potential cooperation between HR-HPV and EBV for HNC development. Considering that: (1) both HR-HPV and EBV infections require cofactors for carcinogenesis; and (2) both oropharyngeal and oral epithelium can be directly exposed to carcinogens, such as alcohol or tobacco smoke, we hypothesize possible interaction mechanisms. The epidemiological and experimental evidence suggests that HR-HPV/EBV cooperation for developing a subset of HNCs is plausible and warrants further investigation.
dc.fuente.origenWOS
dc.identifier.doi10.3390/biology10121232
dc.identifier.eissn2079-7737
dc.identifier.urihttps://doi.org/10.3390/biology10121232
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94035
dc.identifier.wosidWOS:000735966600001
dc.issue.numero12
dc.language.isoen
dc.revistaBiology-basel
dc.rightsacceso restringido
dc.subjectEpstein-Barr virus
dc.subjecthuman papillomavirus
dc.subjecthead and neck cancer
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHigh-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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