Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

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dc.contributor.authorWain, Louise V.
dc.contributor.authorVerwoert, Germaine C.
dc.contributor.authorO'Reilly, Paul F.
dc.contributor.authorShi, Gang
dc.contributor.authorJohnson, Toby
dc.contributor.authorJohnson, Andrew D.
dc.contributor.authorBochud, Murielle
dc.contributor.authorRice, Kenneth M.
dc.contributor.authorHenneman, Peter
dc.contributor.authorSmith, Albert V.
dc.contributor.authorEhret, Georg B.
dc.contributor.authorAmin, Najaf
dc.contributor.authorLarson, Martin G.
dc.contributor.authorMooser, Vincent
dc.contributor.authorHadley, David
dc.contributor.authorDoerr, Marcus
dc.contributor.authorBis, Joshua C.
dc.contributor.authorAspelund, Thor
dc.contributor.authorEsko, Tonu
dc.contributor.authorJanssens, A. Cecile J. W.
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorHeath, Simon
dc.contributor.authorLaan, Maris
dc.contributor.authorFu, Jingyuan
dc.contributor.authorPistis, Giorgio
dc.contributor.authorLuan, Jian'an
dc.contributor.authorArora, Pankaj
dc.contributor.authorLucas, Gavin
dc.contributor.authorPirastu, Nicola
dc.contributor.authorPichler, Irene
dc.contributor.authorJackson, Anne U.
dc.contributor.authorWebster, Rebecca J.
dc.contributor.authorZhang, Feng
dc.contributor.authorPeden, John F.
dc.contributor.authorSchmidt, Helena
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorCampbell, Harry
dc.contributor.authorIgl, Wilmar
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorVitart, Veronique
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorTrompet, Stella
dc.contributor.authorBragg-Gresham, Jennifer L.
dc.contributor.authorAlizadeh, Behrooz Z.
dc.contributor.authorChambers, John C.
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorLehtimaki, Terho
dc.contributor.authorKuehnel, Brigitte
dc.contributor.authorLopez, Lorna M.
dc.contributor.authorPolasek, Ozren
dc.contributor.authorBoban, Mladen
dc.contributor.authorNelson, Christopher P.
dc.contributor.authorMorrison, Alanna C.
dc.contributor.authorPihur, Vasyl
dc.contributor.authorGanesh, Santhi K.
dc.contributor.authorHofman, Albert
dc.contributor.authorKundu, Suman
dc.contributor.authorMattace-Raso, Francesco U. S.
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorSijbrands, Eric J. G.
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorHwang, Shih-Jen
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorWang, Thomas J.
dc.contributor.authorBergmann, Sven
dc.contributor.authorVollenweider, Peter
dc.contributor.authorWaeber, Gerard
dc.contributor.authorLaitinen, Jaana
dc.contributor.authorPouta, Anneli
dc.contributor.authorZitting, Paavo
dc.contributor.authorMcArdle, Wendy L.
dc.contributor.authorKroemer, Heyo K.
dc.contributor.authorVoelker, Uwe
dc.contributor.authorVoelzke, Henry
dc.contributor.authorGlazer, Nicole L.
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorAlavere, Helene
dc.contributor.authorHaller, Toomas
dc.contributor.authorKeis, Aime
dc.contributor.authorTammesoo, Mari-Liis
dc.contributor.authorAulchenko, Yurii
dc.contributor.authorBarroso, Ines
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorGalan, Pilar
dc.contributor.authorHercberg, Serge
dc.contributor.authorLathrop, Mark
dc.contributor.authorEyheramendy, Susana
dc.contributor.authorOrg, Elin
dc.contributor.authorSober, Siim
dc.contributor.authorLu, Xiaowen
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorPenninx, Brenda W.
dc.contributor.authorCorre, Tanguy
dc.contributor.authorMasciullo, Corrado
dc.contributor.authorSala, Cinzia
dc.contributor.authorGroop, Leif
dc.contributor.authorVoight, Benjamin F.
dc.contributor.authorMelander, Olle
dc.contributor.authorO'Donnell, Christopher J.
dc.contributor.authorSalomaa, Veikko
dc.contributor.authord'Adamo, Adamo Pio
dc.contributor.authorFabretto, Antonella
dc.contributor.authorFaletra, Flavio
dc.contributor.authorUlivi, Sheila
dc.contributor.authorDel Greco, Fabiola M.
dc.contributor.authorFacheris, Maurizio
dc.contributor.authorCollins, Francis S.
dc.contributor.authorBergman, Richard N.
dc.contributor.authorBeilby, John P.
dc.contributor.authorHung, Joseph
dc.contributor.authorMusk, A. William
dc.contributor.authorMangino, Massimo
dc.contributor.authorShin, So-Youn
dc.contributor.authorSoranzo, Nicole
dc.contributor.authorWatkins, Hugh
dc.contributor.authorGoel, Anuj
dc.contributor.authorHamsten, Anders
dc.contributor.authorGider, Pierre
dc.contributor.authorLoitfelder, Marisa
dc.contributor.authorZeginigg, Marion
dc.contributor.authorHernandez, Dena
dc.contributor.authorNajjar, Samer S.
dc.contributor.authorNavarro, Pau
dc.contributor.authorWild, Sarah H.
dc.contributor.authorCorsi, Anna Maria
dc.contributor.authorSingleton, Andrew
dc.contributor.authorde Geus, Eco J. C.
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorParker, Alex N.
dc.contributor.authorRose, Lynda M.
dc.contributor.authorBuckley, Brendan
dc.contributor.authorStott, David
dc.contributor.authorOrru, Marco
dc.contributor.authorUda, Manuela
dc.contributor.authorvan der Klauw, Melanie M.
dc.contributor.authorZhang, Weihua
dc.contributor.authorLi, Xinzhong
dc.contributor.authorScott, James
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorBurke, Gregory L.
dc.contributor.authorKahonen, Mika
dc.contributor.authorViikari, Jorma
dc.contributor.authorDoering, Angela
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorDavies, Gail
dc.contributor.authorStarr, John M.
dc.contributor.authorEmilsson, Valur
dc.contributor.authorPlump, Andrew
dc.contributor.authorLindeman, Jan H.
dc.contributor.author't Hoen, Peter A. C.
dc.contributor.authorKoenig, Inke R.
dc.contributor.authorFelix, Janine F.
dc.contributor.authorClarke, Robert
dc.contributor.authorHopewell, Jemma C.
dc.contributor.authorOngen, Halit
dc.contributor.authorBreteler, Monique
dc.contributor.authorDebette, Stephanie
dc.contributor.authorDeStefano, Anita L.
dc.contributor.authorFornage, Myriam
dc.contributor.authorMitchell, Gary F.
dc.contributor.authorSmith, Nicholas L.
dc.contributor.authorHolm, Hilma
dc.contributor.authorStefansson, Kari
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorSamani, Nilesh J.
dc.contributor.authorPreuss, Michael
dc.contributor.authorRudan, Igor
dc.contributor.authorHayward, Caroline
dc.contributor.authorDeary, Ian J.
dc.contributor.authorWichmann, H-Erich
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorPalmas, Walter
dc.contributor.authorKooner, Jaspal S.
dc.contributor.authorStolk, Ronald P.
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorWright, Alan F.
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBandinelli, Stefania
dc.contributor.authorGyllensten, Ulf B.
dc.contributor.authorWilson, James F.
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorFarrall, Martin
dc.contributor.authorSpector, Tim D.
dc.contributor.authorPalmer, Lyle J.
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorPfeufer, Arne
dc.contributor.authorGasparini, Paolo
dc.contributor.authorSiscovick, David
dc.contributor.authorAltshuler, David
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorToniolo, Daniela
dc.contributor.authorSnieder, Harold
dc.contributor.authorGieger, Christian
dc.contributor.authorMeneton, Pierre
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorOostra, Ben A.
dc.contributor.authorMetspalu, Andres
dc.contributor.authorLauner, Lenore
dc.contributor.authorRettig, Rainer
dc.contributor.authorStrachan, David P.
dc.contributor.authorBeckmann, Jacques S.
dc.contributor.authorWitteman, Jacqueline C. M.
dc.contributor.authorErdmann, Jeanette
dc.contributor.authorvan Dijk, Ko Willems
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBoehnke, Michael
dc.contributor.authorRidker, Paul M.
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorChakravarti, Aravinda
dc.contributor.authorAbecasis, Goncalo R.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorNewton-Cheh, Christopher
dc.contributor.authorLevy, Daniel
dc.contributor.authorMunroe, Patricia B.
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorCaulfield, Mark J.
dc.contributor.authorRao, Dabeeru C.
dc.contributor.authorTobin, Martin D.
dc.contributor.authorElliott, Paul
dc.contributor.authorvan Duijn, Cornelia M.
dc.date.accessioned2025-01-21T00:00:41Z
dc.date.available2025-01-21T00:00:41Z
dc.date.issued2011
dc.description.abstractNumerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
dc.fuente.origenWOS
dc.identifier.doi10.1038/ng.922
dc.identifier.issn1061-4036
dc.identifier.urihttps://doi.org/10.1038/ng.922
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95352
dc.identifier.wosidWOS:000295316200017
dc.issue.numero10
dc.language.isoen
dc.pagina.finalU122
dc.pagina.inicio1005
dc.revistaNature genetics
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
dc.typeartículo
dc.volumen43
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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