Preparation and characterisation of quillaja saponin with less heterogeneity than Quil-A

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dc.contributor.authorKamstrup, S
dc.contributor.authorSan Martin, R
dc.contributor.authorDoberti, A
dc.contributor.authorGrande, H
dc.contributor.authorDalsgaard, K
dc.date.accessioned2025-01-21T01:31:25Z
dc.date.available2025-01-21T01:31:25Z
dc.date.issued2000
dc.description.abstractImmunisation against pathogens remains one of the most effective ways of preventing or reducing losses due to infectious diseases in animal husbandry. When inactivated vaccines are used, adjuvants are most often required to obtain satisfactory immune responses. One such type of adjuvant is saponin derived from the bark of Quillaja saponaria Molina, a tree of the rose family. A few different commercial sources exist, but due to the structural complexity and heterogeneity of these saponin preparations, it has been difficult to establish exactly which components are responsible for the adjuvant activity. By carefully selecting the bark source, live have succeeded in preparing a much less heterogeneous preparation of quillaja saponin. In this report we describe the preparation, in terms of structural complexity, hemolytic activity, adjuvant activity, and its ability to form ISCOM matrix. This new preparation could have implications for use per se, or as starting material for more effective preparation of pure substances. (C) 2000 Elsevier Science Ltd. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn0264-410X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97062
dc.identifier.wosidWOS:000086683400010
dc.issue.numero21
dc.language.isoen
dc.pagina.final2249
dc.pagina.inicio2244
dc.revistaVaccine
dc.rightsacceso restringido
dc.subjectQuil A
dc.subjectadjuvant
dc.subjectsaponin
dc.subjectISCOM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePreparation and characterisation of quillaja saponin with less heterogeneity than Quil-A
dc.typeartículo
dc.volumen18
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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