Spinal cord regeneration in Xenopus tadpoles proceeds through activation of Sox2-positive cells

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dc.contributor.authorGaete Carrasco, Marcia
dc.contributor.authorValle Muñoz Videla, Rosana del.
dc.contributor.authorSánchez, Natalia.
dc.contributor.authorTampe, Ricardo.
dc.contributor.authorMoreno Concha, Mauricio
dc.contributor.authorContreras, Esteban G.
dc.contributor.authorLee Liu, Dasfne.
dc.contributor.authorLarraín Correa, Juan Agustín
dc.date.accessioned2019-10-17T18:22:11Z
dc.date.available2019-10-17T18:22:11Z
dc.date.issued2012
dc.date.updated2019-10-14T18:57:09Z
dc.description.abstractAbstract Background In contrast to mammals, amphibians, such as adult urodeles (for example, newts) and anuran larvae (for example, Xenopus) can regenerate their spinal cord after injury. However, the cellular and molecular mechanisms involved in this process are still poorly understood. Results Here, we report that tail amputation results in a global increase of Sox2 levels and proliferation of Sox2+ cells. Overexpression of a dominant negative form of Sox2 diminished proliferation of spinal cord resident cells affecting tail regeneration after amputation, suggesting that spinal cord regeneration is crucial for the whole process. After spinal cord transection, Sox2+ cells are found in the ablation gap forming aggregates. Furthermore, Sox2 levels correlated with regenerative capabilities during metamorphosis, observing a decrease in Sox2 levels at non-regenerative stages. Conclusions Sox2+ cells contribute to the regeneration of spinal cord after tail amputation and transection. Sox2 levels decreases during metamorphosis concomitantly with the lost of regenerative capabilities. Our results lead to a working hypothesis in which spinal cord damage activates proliferation and/or migration of Sox2+ cells, thus allowing regeneration of the spinal cord after tail amputation or reconstitution of the ependymal epithelium after spinal cord transection.
dc.fuente.origenBiomed Central
dc.identifier.citationNeural Development. 2012 Apr 26;7(1):13
dc.identifier.doi10.1186/1749-8104-7-13
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26833
dc.issue.numeroNo.13
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.revistaNeural Developmentes_ES
dc.rightsacceso abierto
dc.rights.holderGaete et al.; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherNeurocienciases_ES
dc.subject.otherBiología del desarrolloes_ES
dc.subject.otherNeurobiologíaes_ES
dc.subject.otherMédula espinales_ES
dc.titleSpinal cord regeneration in Xenopus tadpoles proceeds through activation of Sox2-positive cellses_ES
dc.typeartículo
dc.volumenVol.7
sipa.codpersvinculados1007357
sipa.codpersvinculados149693
sipa.codpersvinculados117716
sipa.codpersvinculados90468
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