Genome sequencing and analysis of the biomass-degrading fungus <i>Trichoderma reesei</i> (syn. <i>Hypocrea jecorina</i>)

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dc.contributor.authorMartinez, Diego
dc.contributor.authorBerka, Randy M.
dc.contributor.authorHenrissat, Bernard
dc.contributor.authorSaloheimo, Markku
dc.contributor.authorArvas, Mikko
dc.contributor.authorBaker, Scott E.
dc.contributor.authorChapman, Jarod
dc.contributor.authorChertkov, Olga
dc.contributor.authorCoutinho, Pedro M.
dc.contributor.authorCullen, Dan
dc.contributor.authorDanchin, Etienne G. J.
dc.contributor.authorGrigoriev, Igor V.
dc.contributor.authorHarris, Paul
dc.contributor.authorJackson, Melissa
dc.contributor.authorKubicek, Christian P.
dc.contributor.authorHan, Cliff S.
dc.contributor.authorHo, Isaac
dc.contributor.authorLarrondo, Luis F.
dc.contributor.authorde Leon, Alfredo Lopez
dc.contributor.authorMagnuson, Jon K.
dc.contributor.authorMerino, Sandy
dc.contributor.authorMisra, Monica
dc.contributor.authorNelson, Beth
dc.contributor.authorPutnam, Nicholas
dc.contributor.authorRobbertse, Barbara
dc.contributor.authorSalamov, Asaf A.
dc.contributor.authorSchmoll, Monika
dc.contributor.authorTerry, Astrid
dc.contributor.authorThayer, Nina
dc.contributor.authorWesterholm-Parvinen, Ann
dc.contributor.authorSchoch, Conrad L.
dc.contributor.authorYao, Jian
dc.contributor.authorBarbote, Ravi
dc.contributor.authorNelson, Mary Anne
dc.contributor.authorDetter, Chris
dc.contributor.authorBruce, David
dc.contributor.authorKuske, Cheryl R.
dc.contributor.authorXie, Gary
dc.contributor.authorRichardson, Paul
dc.contributor.authorRokhsar, Daniel S.
dc.contributor.authorLucas, Susan M.
dc.contributor.authorRubin, Edward M.
dc.contributor.authorDunn-Coleman, Nigel
dc.contributor.authorWard, Michael
dc.contributor.authorBrettin, Thomas S.
dc.date.accessioned2025-01-21T01:05:06Z
dc.date.available2025-01-21T01:05:06Z
dc.date.issued2008
dc.description.abstractTrichoderma reesei is the main industrial source of cellulases and hemicellulases used to depolymerize biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. We assembled 89 scaffolds (sets of ordered and oriented contigs) to generate 34 Mbp of nearly contiguous T. reesei genome sequence comprising 9,129 predicted gene models. Unexpectedly, considering the industrial utility and effectiveness of the carbohydrate-active enzymes of T. reesei, its genome encodes fewer cellulases and hemicellulases than any other sequenced fungus able to hydrolyze plant cell wall polysaccharides. Many T. reesei genes encoding carbohydrate-active enzymes are distributed nonrandomly in clusters that lie between regions of synteny with other Sordariomycetes. Numerous genes encoding biosynthetic pathways for secondary metabolites may promote survival of T. reesei in its competitive soil habitat, but genome analysis provided little mechanistic insight into its extraordinary capacity for protein secretion. Our analysis, coupled with the genome sequence data, provides a roadmap for constructing enhanced T. reesei strains for industrial applications such as biofuel production.
dc.description.funderNIGMS NIH HHS
dc.fuente.origenWOS
dc.identifier.doi10.1038/nbt1403
dc.identifier.eissn1546-1696
dc.identifier.issn1087-0156
dc.identifier.urihttps://doi.org/10.1038/nbt1403
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95816
dc.identifier.wosidWOS:000255756800028
dc.issue.numero5
dc.language.isoen
dc.pagina.final560
dc.pagina.inicio553
dc.revistaNature biotechnology
dc.rightsacceso restringido
dc.subject.ods07 Affordable and Clean Energy
dc.subject.ods12 Responsible Consumption and Production
dc.subject.odspa07 Energía asequible y no contaminante
dc.subject.odspa12 Producción y consumo responsable
dc.titleGenome sequencing and analysis of the biomass-degrading fungus <i>Trichoderma reesei</i> (syn. <i>Hypocrea jecorina</i>)
dc.typeartículo
dc.volumen26
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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