Herpes Simplex Virus Type 1 Infection of the Central Nervous System : Insights Into Proposed Interrelationships With Neurodegenerative Disorders

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dc.article.number46
dc.catalogadorgrr
dc.contributor.authorDuarte Peñaloza, Luisa Fernanda
dc.contributor.authorFarías León, Mónica Andrea
dc.contributor.authorÁlvarez Espejo, Diana Claudia Marcela
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorRiedel Soria, Claudia
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.contributor.editorGonzalez-Dunia, Daniel
dc.date.accessioned2024-01-24T22:56:30Z
dc.date.available2024-01-24T22:56:30Z
dc.date.issued2019
dc.description.abstractHerpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain without evident clinical symptoms. Once in the central nervous system (CNS), the virus can either reside in a quiescent latent state in this tissue, or eventually actively lead to severe acute necrotizing encephalitis, which is characterized by exacerbated neuroinflammation and prolonged neuroimmune activation producing a life-threatening disease. Although HSV-1 encephalitis can be treated with antivirals that limit virus replication, neurological sequelae are common and the virus will nevertheless remain for life in the neural tissue. Importantly, there is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders. Here, we review and discuss acute and chronic infection of particular brain regions by HSV-1 and how this may affect neuron and cognitive functions in the host. We review potential cellular and molecular mechanisms leading to neurodegeneration, such as protein aggregation, dysregulation of autophagy, oxidative cell damage and apoptosis, among others. Furthermore, we discuss the impact of HSV-1 infection on brain inflammation and its potential relationship with neurodegenerative diseases.
dc.fechaingreso.objetodigital2024-01-24
dc.format.extent16 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3389/fncel.2019.00046
dc.identifier.issn1662-5102
dc.identifier.pubmedid30863282
dc.identifier.scopusidSCOPUS_ID:85064224296
dc.identifier.urihttps://doi.org/10.3389/fncel.2019.00046
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80949
dc.identifier.wosidWOS:000459739900001
dc.information.autorucFacultad de Ciencias Biológicas; Duarte Peñaloza, Luisa Fernanda; 0000-0003-1828-1800; 1031205
dc.information.autorucFacultad de Ciencias Biológicas; Farías León, Mónica Andrea; 0000-0003-0550-2002; 205467
dc.information.autorucFacultad de Ciencias Biológicas; Álvarez Espejo, Diana Claudia Marcela; S/I; 250646
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Riedel Soria, Claudia; S/I; 88772
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.language.isoen
dc.nota.accesoContenido completo
dc.relation.ispartofResearch Topics: Molecular and Cellular Mechanisms of Nervous System Infections: Frontiers, 2019.
dc.revistaFrontiers in Cellular Neuroscience
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectHerpes simplex virus
dc.subjectneurodegeneration
dc.subjectNeurological disease
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectMitochondrial damage
dc.subjectOxidative stress
dc.subjectNeuroinflammation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHerpes Simplex Virus Type 1 Infection of the Central Nervous System : Insights Into Proposed Interrelationships With Neurodegenerative Disorders
dc.typeartículo de revisión
dc.volumen13
sipa.codpersvinculados1031205
sipa.codpersvinculados205467
sipa.codpersvinculados250646
sipa.codpersvinculados113541
sipa.codpersvinculados88772
sipa.codpersvinculados15616
sipa.trazabilidadORCID;2024-01-15
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