Comparison of molecular changes in cervical intraepithelial neoplasia in HIV-positive and HIV-indeterminate subjects

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dc.contributor.authorWistuba, II
dc.contributor.authorSyed, S
dc.contributor.authorBehrens, C
dc.contributor.authorDuong, M
dc.contributor.authorMilchgrub, S
dc.contributor.authorMuller, CY
dc.contributor.authorJagirdar, J
dc.contributor.authorGazdar, AF
dc.date.accessioned2024-01-10T12:04:43Z
dc.date.available2024-01-10T12:04:43Z
dc.date.issued1999
dc.description.abstractObjective. HIV infection is associated with an increased incidence of cervical malignancy and its precursor lesions (CIN, cervical intraepithelial neoplasia) compared with the general population. We studied the molecular abnormalities in the development of HIV-associated CIN and compared them with those present in CINs arising in HIV-indeterminate subjects ("sporadic CIN").
dc.description.abstractMethods. We investigated the presence of human papilloma virus (HPV) sequences, loss of heterozygosity (LOH), and microsatellite alterations (MAs) at five 3p chromosomal regions using 17 polymorphic markers in precisely microdissected archival tissues from 16 HIV-positive CINs and compared them with those present in 39 sporadic CINs.
dc.description.abstractResults. HPV sequences were detected in 36 of 55 (66%) CIN lesions, and high-risk oncogenic strains (HPV 16 and 18) accounted for 15 of them. No differences in the HPV frequencies were found between HIV-associated and sporadic CINs. Allelic losses at one or more chromosome 3p regions were frequently detected in CIN lesions (49%). The overall frequency of 3p LOH and the frequencies at all individual regions were similar in HIV-associated and sporadic CINs. The frequency of MA present in the HIV-associated CIN cases (0.093) was sixfold greater than in sporadic CINs (0.01 1; P = 0.0001). At least 1 MA was present in 11 (69%) of 16 HIV-associated vs 5 of 39 (13%) sporadic CIN (P = 0.0006). Molecular changes were independent of the presence of HPV sequences.
dc.description.abstractConclusion, Chromosome 3p deletions are frequently detected in the precursor lesions of cervical carcinoma (CIN) and there are no differences in the 3p LOH frequencies between HIV-associated and sporadic CIN lesions. Microsatellite alterations, which reflect widespread genomic instability, occur at greatly increased frequency in HIV-associated GIN. Although the mechanism underlying the development of increased MAs is unknown, it may play a crucial role in the development of many HIV-associated neoplasias. (C) 1999 Academic Press.
dc.fechaingreso.objetodigital2024-04-12
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1006/gyno.1999.5485
dc.identifier.eissn1095-6859
dc.identifier.issn0090-8258
dc.identifier.pubmedidMEDLINE:10479524
dc.identifier.urihttps://doi.org/10.1006/gyno.1999.5485
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75864
dc.identifier.wosidWOS:000082708100037
dc.information.autorucMedicina;Wistuba I;S/I;100278
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final526
dc.pagina.inicio519
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaGYNECOLOGIC ONCOLOGY
dc.rightsacceso restringido
dc.subjectcervical carcinoma
dc.subjectCIN
dc.subjectAIDS-related neoplasms
dc.subjectHIV infection
dc.subjectHPV infection
dc.subjectchromosome 3p
dc.subjectMICROSATELLITE INSTABILITY
dc.subjectCHROMOSOME 3P
dc.subjectCANCER
dc.subjectPATHOGENESIS
dc.subjectCARCINOMA
dc.subjectFREQUENT
dc.subjectALLELOTYPE
dc.subjectDELETIONS
dc.subjectPHENOTYPE
dc.subjectLYMPHOMA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleComparison of molecular changes in cervical intraepithelial neoplasia in HIV-positive and HIV-indeterminate subjects
dc.typeartículo
dc.volumen74
sipa.codpersvinculados100278
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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