Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus

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dc.contributor.authorChang, Lily Y-L
dc.contributor.authorArdiles, Alvaro O.
dc.contributor.authorTapia-Rojas, Cheril
dc.contributor.authorAraya, Joaquin
dc.contributor.authorInestrosa, Nibaldo C.
dc.contributor.authorPalacios, Adrian G.
dc.contributor.authorAcosta, Monica L.
dc.date.accessioned2025-01-23T19:52:34Z
dc.date.available2025-01-23T19:52:34Z
dc.date.issued2020
dc.description.abstractAccumulation of amyloid-beta (A beta) peptides is regarded as the hallmark of neurodegenerative alterations in the brain of Alzheimer's disease (AD) patients. In the eye, accumulation of A beta peptides has also been suggested to be a trigger of retinal neurodegenerative mechanisms. Some pathological aspects associated with A beta levels in the brain are synaptic dysfunction, neurochemical remodeling and glial activation, but these changes have not been established in the retina of animals with A beta accumulation. We have employed the Octodon degus in which A beta peptides accumulated in the brain and retina as a function of age. This current study investigated microglial morphology, expression of PSD95, synaptophysin, Iba-1 and choline acetyltransferase (ChAT) in the retina of juvenile, young and adult degus using immunolabeling methods. Neurotransmitters glutamate and gamma-aminobutyric acid (GABA) were detected using immunogold labeling and glutamate receptor subunits were quantified using Western blotting. There was an age-related increase in presynaptic and a decrease in post-synaptic retinal proteins in the retinal plexiform layers. Immunolabeling showed changes in microglial morphology characteristic of intermediate stages of activation around the optic nerve head (ONH) and decreasing activation toward the peripheral retina. Neurotransmitter expression pattern changed at juvenile ages but was similar in adults. Collectively, the results suggest that microglial activation, synaptic remodeling and neurotransmitter changes may be consequent to, or parallel to A beta peptide and phosphorylated tau accumulation in the retina.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fnins.2020.00161
dc.identifier.eissn1662-453X
dc.identifier.urihttps://doi.org/10.3389/fnins.2020.00161
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100635
dc.identifier.wosidWOS:000525605400001
dc.language.isoen
dc.revistaFrontiers in neuroscience
dc.rightsacceso restringido
dc.subjectretina remodeling
dc.subjectamyloid protein
dc.subjectaging
dc.subjectAlzheimer's disease
dc.subjectOctodon degus
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEvidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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