Ovarian reserve and premature ovarian failure in girls and adolescents after hematopoietic stem cell transplantation

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dc.contributor.authorParis, Claudia
dc.contributor.authorZepeda, Ana
dc.contributor.authorMunoz, Monica
dc.contributor.authorCamus, Adela
dc.contributor.authorCatalan, Paula
dc.contributor.authorSotomayor, Cristian
dc.contributor.authorLuengo, Rosario
dc.contributor.authorSchulin-Zeuthem, Carolina
dc.contributor.authorBrieba, Mariela
dc.contributor.authorRomero, Patricia
dc.date.accessioned2025-01-20T20:22:28Z
dc.date.available2025-01-20T20:22:28Z
dc.date.issued2022
dc.description.abstractThe increased survival of children and adolescents after Stem Cell Transplantation (SCT) has allowed us to gain a better understanding of the late effects that this procedure might have. Objective: to measure ovarian function and reserve after SCT. Patients and Method: A descriptive, observational, and cross-sectional study of girls and adolescents with SCT between 1999 and 2011. External gynecologic examination, hormone tests, and abdominal gynecologic ultrasound were performed, observing pubertal development pre-SCT. The following data from the clinical record were recorded: baseline pathology, type of conditioning, use of radiotherapy in conditioning, age at the time of SCT, and history of acute or chronic graft-versus-host disease (GVHD). Hormonal tests included folliclestimulating hormone (FSH), luteinizing hormone (LH), estradiol, prolactin (PRL), thyroid-stimulating hormone (TSH), free thyroxine, total testosterone, sex hormone-binding globulin (SHBG), and anti-Mullerian hormone (AMH). Statistical analysis included the chi-square or Fisher's Exact test with a p-value < 0.05. Results: 41 patients were evaluated. The median age at the time of SCT was 6.8 years (1.5-14.1) and the median age at evaluation was 14.8 years (range: 4-25.4 years). 93% of the transplants were in patients with oncological disease and with myeloablative conditioning regimens. All patients presented decreased ovarian reserve, and 72% showed Premature Ovarian Failure (POF). Conclusions: All patients had decreased ovarian reserve and most of them had a high prevalence of POF. Before SCT, a gynecological evaluation and subsequent follow-up for hormone monitoring and initiation of hormone replacement are essential.
dc.fuente.origenWOS
dc.identifier.doi10.32641/andespediatr.v93i1.3693
dc.identifier.eissn2452-6053
dc.identifier.issn****_****
dc.identifier.urihttps://doi.org/10.32641/andespediatr.v93i1.3693
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92679
dc.identifier.wosidWOS:001072643600003
dc.issue.numero1
dc.language.isoen
dc.pagina.final26
dc.pagina.inicio19
dc.revistaAndes pediatrica
dc.rightsacceso restringido
dc.subjectPremature Ovarian Failure
dc.subjectStem Cell Transplantation
dc.subjectLate Effects
dc.subjectFertility
dc.subjectPediatric
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleOvarian reserve and premature ovarian failure in girls and adolescents after hematopoietic stem cell transplantation
dc.typeartículo
dc.volumen93
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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