Functional cardiac MRI in preterm and term newborns

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dc.contributor.authorGroves, Alan M.
dc.contributor.authorChiesa, Gaia
dc.contributor.authorDurighel, Giuliana
dc.contributor.authorGoldring, Stephen T.
dc.contributor.authorFitzpatrick, Julie A.
dc.contributor.authorUribe, Sergio
dc.contributor.authorRazavi, Reza
dc.contributor.authorHajnal, Jo V.
dc.contributor.authorEdwards, A. David
dc.date.accessioned2024-01-10T12:05:38Z
dc.date.available2024-01-10T12:05:38Z
dc.date.issued2011
dc.description.abstractObjective To use cardiac MRI techniques to assess ventricular function and systemic perfusion in preterm and term newborns, to compare techniques to echocardiographic methods, and to obtain initial reference data.
dc.description.abstractDesign Observational magnetic resonance and echocardiographic imaging study.
dc.description.abstractSetting Neonatal Unit, Queen Charlotte's and Chelsea Hospital, London, UK.
dc.description.abstractPatients 108 newborn infants with median birth weight 1627 (580-4140) g, gestation 32 (25-42) weeks.
dc.description.abstractResults Mean (SD) flow volumes assessed by phase contrast (PC) imaging in 28 stable infants were left ventricular output (LVO) 222 (46), right ventricular output (RVO) 219 (47), superior vena cava (SVC) 95 (27) and descending aorta (DAo) 126 (32) ml/kg/min, with flow being higher at lower gestational age. Limits of agreement for repeated PC assessment of flow were LVO +/- 50.2, RVO +/- 55.5, SVC +/- 20.9 and DAo +/- 26.2 ml/kg/min. Mean (SD) LVO in 75 stable infants from three-dimensional models were 245 (47) ml/kg/min, with limits of agreement +/- 58.3 ml/kg/min. Limits of agreement for repeated echocardiographic assessment of LVO were +/- 108.9 ml/kg/min.
dc.description.abstractConclusions Detailed magnetic resonance assessments of cardiac function and systemic perfusion are feasible in newborn infants, and provide more complete data with greater reproducibility than existing echocardiographic methods. Functional cardiac MRI could prove to be a useful research technique to study small numbers of newborn infants in specialist centres; providing insights into the pathophysiology of circulatory failure; acting as an outcome measure in clinical trials of inotropic intervention and so guiding clinical practice in the wider neonatal community.
dc.description.funderGarfield Weston Foundation
dc.description.funderMedical Research Council
dc.description.funderWellcome Trust
dc.description.funderImperial College Comprehensive Biomedical Research Centre
dc.description.funderDorothy Hodgkins Postgraduate Award
dc.description.funderPhilips
dc.description.funderBritish Heart Foundation
dc.description.funderMedical Research Council
dc.fechaingreso.objetodigital2024-05-06
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1136/adc.2010.189142
dc.identifier.issn1359-2998
dc.identifier.pubmedidMEDLINE:20971721
dc.identifier.urihttps://doi.org/10.1136/adc.2010.189142
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76042
dc.identifier.wosidWOS:000287986800003
dc.information.autorucMedicina;Uribe S ;S/I;16572
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherB M J PUBLISHING GROUP
dc.revistaARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
dc.rightsacceso abierto
dc.subjectCARDIOVASCULAR MAGNETIC-RESONANCE
dc.subjectSYSTEMIC BLOOD-FLOW
dc.subjectSUPERIOR VENA-CAVA
dc.subjectHEART-FAILURE
dc.subjectINFANTS
dc.subjectPRESSURE
dc.subjectOUTPUT
dc.subjectECHOCARDIOGRAPHY
dc.subjectREPEATABILITY
dc.subjectAGE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFunctional cardiac MRI in preterm and term newborns
dc.typeartículo
dc.volumen96
sipa.codpersvinculados16572
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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