Cellular immune responses in amniotic fluid of women with a sonographic short cervix

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dc.contributor.authorGalaz, Jose
dc.contributor.authorRomero, Roberto
dc.contributor.authorXu, Yi
dc.contributor.authorMiller, Derek
dc.contributor.authorLevenson, Dustyn
dc.contributor.authorPara, Robert
dc.contributor.authorVarrey, Aneesha
dc.contributor.authorHsu, Richard
dc.contributor.authorTong, Anna
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorHsu, Chaur-Dong
dc.contributor.authorGomez-Lopez, Nardhy
dc.date.accessioned2025-01-23T19:48:00Z
dc.date.available2025-01-23T19:48:00Z
dc.date.issued2020
dc.description.abstractObjectives: A sonographic short cervix is one of the strongest predictors of preterm delivery. However, the cellular immune composition of amniotic fluid in women with a short cervix has not yet been described. Herein, we determined cellular and soluble immune responses in amniotic fluid from pregnant women with a mid-trimester asymptomatic short cervix.
dc.description.abstractMethods: Amniotic fluid samples (n=77) were collected from asymptomatic women with a cervical length between 15 and 25 mm (n=36, short cervix) or <15 mm (n=41, severely short cervix) diagnosed by ultrasound. Flow cytometry and multiplex measurement of cytokines/chemokines were performed.
dc.description.abstractResults: (1) The cellular immune composition of amniotic fluid did not differ between women with a severely short cervix (<= 15 mm) and those with a short cervix 15-25 mm; (2) amniotic fluid concentrations of multiple cytokines/chemokines were higher in women with a severely short cervix (<= 15 mm) than in those with a short cervix 15-25 mm; (3) the cellular immune composition of amniotic fluid did not differ between women with a severely short cervix (<= 15 mm) who ultimately underwent preterm delivery and those who delivered at term; and (4) amniotic fluid concentrations of IL-2, but not other immune mediators, were increased in women with a severely short cervix (<= 15 mm) who ultimately delivered preterm compared to those who delivered at term.
dc.description.abstractConclusions: Women with a severely short cervix (<= 15 mm) have increased concentrations of pro-inflammatory mediators in the amniotic cavity; yet, these do not translate to changes in the cellular immune response.
dc.fuente.origenWOS
dc.identifier.doi10.1515/jpm-2020-0037
dc.identifier.eissn1619-3997
dc.identifier.issn0300-5577
dc.identifier.urihttps://doi.org/10.1515/jpm-2020-0037
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100419
dc.identifier.wosidWOS:000573921700004
dc.issue.numero7
dc.language.isoen
dc.pagina.final676
dc.pagina.inicio665
dc.revistaJournal of perinatal medicine
dc.rightsacceso restringido
dc.subjectamniotic fluid
dc.subjectcytoldne
dc.subjectchemokine
dc.subjectimmune cell
dc.subjectintra-amniotic inflammation
dc.subjectpreterm
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleCellular immune responses in amniotic fluid of women with a sonographic short cervix
dc.typeartículo
dc.volumen48
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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