Age-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (<i>Octodon degus</i>)

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dc.contributor.authorOliva, Carolina A.
dc.contributor.authorRivera, Daniela S.
dc.contributor.authorTorres, Angie K.
dc.contributor.authorLindsay, Carolina B.
dc.contributor.authorTapia-Rojas, Cheril
dc.contributor.authorBozinovic, Francisco
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2025-01-20T20:18:56Z
dc.date.available2025-01-20T20:18:56Z
dc.date.issued2023
dc.description.abstractIn Octodon degus, the aging process is not equivalent between sexes and worsens for females. To determine the beginning of detrimental features in females and the ways in which to improve them, we compared adult females (36 months old) and aged females (72 months old) treated with Andrographolide (ANDRO), the primary ingredient in Andrographis paniculata. Our behavioral data demonstrated that age does not affect recognition memory and preference for novel experiences, but ANDRO increases these at both ages. Sociability was also not affected by age; however, social recognition and long-term memory were lower in the aged females than adults but were restored with ANDRO. The synaptic physiology data from brain slices showed that adults have more basal synaptic efficiency than aged degus; however, ANDRO reduced basal activity in adults, while it increased long-term potentiation (LTP). Instead, ANDRO increased the basal synaptic activity and LTP in aged females. Age-dependent changes were also observed in synaptic proteins, where aged females have higher synaptotagmin (SYT) and lower postsynaptic density protein-95 (PSD95) levels than adults. ANDRO increased the N-methyl D-aspartate receptor subtype 2B (NR2B) at both ages and the PSD95 and Homer1 only in the aged. Thus, females exposed to long-term ANDRO administration show improved complex behaviors related to age-detrimental effects, modulating mechanisms of synaptic transmission, and proteins.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms24021105
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms24021105
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92493
dc.identifier.wosidWOS:000918125600001
dc.issue.numero2
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectOctodon degus
dc.subjectAndrographolide
dc.subjectaging
dc.subjectfemales
dc.subjectsocial memory
dc.subjectsynaptic transmission
dc.subjectsynaptic plasticity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAge-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (<i>Octodon degus</i>)
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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