Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals

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dc.contributor.authorPena, Monica
dc.contributor.authorAmpuero, Manuel
dc.contributor.authorGarces, Carlos
dc.contributor.authorGaggero, Aldo
dc.contributor.authorGarcia, Patricia
dc.contributor.authorSoledad Velasquez, Maria
dc.contributor.authorLuza, Ricardo
dc.contributor.authorAlvarez, Pia
dc.contributor.authorParedes, Fabio
dc.contributor.authorAcevedo, Johanna
dc.contributor.authorFarfan, Mauricio J.
dc.contributor.authorSolari, Sandra
dc.contributor.authorSoto-Rifo, Ricardo
dc.contributor.authorValiente-Echeverria, Fernando
dc.date.accessioned2025-01-20T22:17:01Z
dc.date.available2025-01-20T22:17:01Z
dc.date.issued2021
dc.description.abstractScreening, testing and contact tracing plays a pivotal role in control of the COVID-19 pandemic. To enable this it is necessary to increase the testing capacity. This study compared a SARS-CoV-2 rapid antigen test (RAT) and RT-PCR in 842 asymptomatic individuals from Tarapaca, Chile. A sensitivity of 69.86%, specificity of 99.61%, PPV of 94.44% and NPP of 97.22% with Ct values (Ct > 27) that were significantly higher among individuals with false-negative RAT were reported. These results support the fact that RAT might have a significant impact on the identification of asymptomatic carriers in areas that lack suitable laboratories to perform SARS-CoV-2 real-time RT-PCR diagnostics, or the results take more than 24-48 h, as well as zones with high traffic of individuals such as border/customs, airports, interregional bus, train stations or in any mass testing campaign requiring rapid results.
dc.description.abstract(c) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
dc.description.abstractThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/).
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijid.2021.04.087
dc.identifier.eissn1878-3511
dc.identifier.issn1201-9712
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2021.04.087
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94539
dc.identifier.wosidWOS:000663044700039
dc.language.isoen
dc.pagina.final204
dc.pagina.inicio201
dc.revistaInternational journal of infectious diseases
dc.rightsacceso restringido
dc.subjectRapid antigen test
dc.subjectRAT
dc.subjectSARS-CoV-2
dc.subjectRT-PCR
dc.subjectAsymptomatic
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePerformance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals
dc.typeartículo
dc.volumen107
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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