Hepatic cholesterol transport from plasma into bile: implications for gallstone disease

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dc.catalogadoryvc
dc.contributor.authorZanlungo Matsuhiro, Silvana
dc.contributor.authorRigotti Rivera, Attilio Gianpietro
dc.contributor.authorNervi Oddone, Flavio
dc.date.accessioned2024-06-06T19:19:45Z
dc.date.available2024-06-06T19:19:45Z
dc.date.issued2004
dc.description.abstractPurpose of reviewThe transhepatic traffic of cholesterol from plasma lipoproteins into the bile is critical for overall cholesterol homeostasis and its alterations may lead to cholesterol gallstone formation. This review summarizes recent progress in understanding the key hepatic cholesterol metabolism-related proteins and pathways that influence biliary secretion of cholesterol.Recent findingsIn cholesterol-fed apolipoprotein E knockout mice, the availability of dietary cholesterol for biliary disposal is decreased and diet-induced gallstone formation is impaired. Scavenger receptor class B type I is relevant for cholesterol transport from plasma HDL into the bile in chow-fed mice, however its expression is not critical for biliary cholesterol secretion and gallstone formation in lithogenic diet-fed mice. Intrahepatic cholesterol transport proteins (e.g. sterol carrier protein-2, Niemann Pick type C-1 protein) also determine liver cholesterol available for biliary secretion in mice. Genetic manipulation of canalicular ATP-binding cassette transporter G5 and G8 expression in mice has established their essential role for biliary cholesterol secretion.SummaryRecent studies have underscored that different proteins involved in hepatic cholesterol transport regulate the availability of cholesterol for biliary secretion. These advances may provide new avenues for prevention and treatment of various disease conditions linked to abnormal cholesterol metabolism.
dc.fuente.origenORCID
dc.identifier.doi10.1097/00041433-200406000-00007
dc.identifier.urihttps://doi.org/10.1097/00041433-200406000-00007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86581
dc.identifier.wosidWOS:000221873000007
dc.information.autorucEscuela de Medicina;Zanlungo Matsuhiro, Silvana;0000-0001-8383-9829;72650
dc.information.autorucEscuela de Medicina;Rigotti Rivera, Attilio Gianpietro;0000-0002-0495-3525;68489
dc.information.autorucEscuela de Medicina;Nervi Oddone, Flavio;0000-0002-6642-7985;99156
dc.language.isoen
dc.nota.accesocontenido parcial
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHepatic cholesterol transport from plasma into bile: implications for gallstone disease
dc.typeartículo
sipa.codpersvinculados72650
sipa.trazabilidadORCID;2024-06-03
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