A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)

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dc.contributor.authorRomero, Roberto
dc.contributor.authorFriel, Lara A.
dc.contributor.authorEdwards, Digna R. Velez
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorMazaki Tovi, Shali
dc.contributor.authorVaisbuch, Edi
dc.contributor.authorKim, Chong Jai
dc.contributor.authorErez, Offer
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorPearce, Brad D.
dc.contributor.authorBartlett, Jacquelaine
dc.contributor.authorSalisbury, Benjamin A.
dc.contributor.authorAnant, Madan Kumar
dc.contributor.authorVovis, Gerald F.
dc.contributor.authorLee, Min Seob
dc.contributor.authorGomez, Ricardo
dc.contributor.authorBehnke, Ernesto
dc.contributor.authorOyarzun, Enrique
dc.contributor.authorTromp, Gerard
dc.contributor.authorWilliams, Scott M.
dc.contributor.authorMenon, Ramkumar
dc.date.accessioned2024-01-10T12:37:27Z
dc.date.available2024-01-10T12:37:27Z
dc.date.issued2010
dc.description.abstractOBJECTIVE: We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM).
dc.description.abstractSTUDY DESIGN: A case-control study was conducted in patients with pPROM (225 mothers and 155 fetuses) and 599 mothers and 628 fetuses with a normal pregnancy; 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; false discovery rate was used to correct for multiple testing (q(star) = 0.15).
dc.description.abstractRESULTS: First, a SNP in tissue inhibitor of metalloproteinase 2 in mothers was significantly associated with pPROM (odds ratio, 2.12; 95% confidence interval, 1.47-3.07; P = .000068), and this association remained significant after correction for multiple comparisons. Second, haplotypes for Alpha 3 type IV collagen isoform precursor in the mother were associated with pPROM ( global P = .003). Third, multilocus analysis identified a 3-locus model, which included maternal SNPs in collagen type I alpha 2, defensin alpha 5 gene, and endothelin 1.
dc.description.abstractCONCLUSION: DNA variants in a maternal gene involved in extracellular matrix metabolism doubled the risk of pPROM.
dc.description.funderPerinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.description.funderNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
dc.fechaingreso.objetodigital2024-03-19
dc.format.extent30 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ajog.2010.05.026
dc.identifier.eissn1097-6868
dc.identifier.issn0002-9378
dc.identifier.pubmedidMEDLINE:20673868
dc.identifier.urihttps://doi.org/10.1016/j.ajog.2010.05.026
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76852
dc.identifier.wosidWOS:000282287000034
dc.information.autorucMedicina; Gomez R;S/I;80926
dc.information.autorucMedicina;Behnke E ;S/I;98656
dc.information.autorucMedicina;Oyarzun E ;S/I;54261
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherMOSBY-ELSEVIER
dc.revistaAMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
dc.rightsacceso restringido
dc.subjectchorioamnionitis
dc.subjectDNA variants
dc.subjectextracellular matrix
dc.subjectgenetic association study
dc.subjectgenomics
dc.subjectgenotype
dc.subjecthaplotype
dc.subjecthigh dimensional biology
dc.subjectmatrix metalloproteinase
dc.subjectparturition
dc.subjectprematurity
dc.subjectpreterm prelabor rupture of membranes
dc.subjectsingle-nucleotide polymorphism
dc.subjectTUMOR-NECROSIS-FACTOR
dc.subjectINTERLEUKIN-1 RECEPTOR ANTAGONIST
dc.subjectMIDTRIMESTER AMNIOTIC-FLUID
dc.subjectFACTOR-ALPHA GENE
dc.subjectSINGLE NUCLEOTIDE POLYMORPHISM
dc.subjectEHLERS-DANLOS-SYNDROME
dc.subjectFALSE DISCOVERY RATE
dc.subjectHUMAN UTERINE CERVIX
dc.subjectTHAN-G POLYMORPHISM
dc.subjectPREMATURE-RUPTURE
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleA genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
dc.typeartículo
dc.volumen203
sipa.codpersvinculados80926
sipa.codpersvinculados98656
sipa.codpersvinculados54261
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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