From Shadows to Spotlight: Exploring the Escalating Burden of Alcohol-Associated Liver Disease and Alcohol Use Disorder in Young Women

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dc.contributor.authorDanpanichkul, Pojsakorn
dc.contributor.authorNg, Cheng Han
dc.contributor.authorMuthiah, Mark
dc.contributor.authorSuparan, Kanokphong
dc.contributor.authorTan, Darren Jun Hao
dc.contributor.authorDuangsonk, Kwanjit
dc.contributor.authorSukphutanan, Banthoon
dc.contributor.authorKongarin, Siwanart
dc.contributor.authorHarinwan, Nateeluck
dc.contributor.authorPanpradist, Nuttada
dc.contributor.authorTakahashi, Hirokazu
dc.contributor.authorKawaguchi, Takumi
dc.contributor.authorVichitkunakorn, Polathep
dc.contributor.authorChaiyakunapruk, Nathorn
dc.contributor.authorNathisuwan, Surakit
dc.contributor.authorHuang, Daniel
dc.contributor.authorArab, Juan Pablo
dc.contributor.authorNoureddin, Mazen
dc.contributor.authorMellinger, Jessica Leigh
dc.contributor.authorWijarnpreecha, Karn
dc.date.accessioned2025-01-20T16:11:24Z
dc.date.available2025-01-20T16:11:24Z
dc.date.issued2024
dc.description.abstractINTRODUCTION: The burden of alcohol-related complications is considerable, particularly alcohol-associated liver disease and alcohol use disorder (AUD). However, there are deficiencies in comprehensive epidemiological research focusing on these issues, especially among young women who display higher susceptibility to such complications compared with their male counterparts. We thus aimed to determine the global burden of these conditions in this vulnerable group.
dc.description.abstractMETHODS: Leveraging data from the Global Burden of Disease Study 2019, we analyzed the prevalence, mortality, and disability-adjusted life years of alcohol-associated cirrhosis (AC), liver cancer from alcohol, and AUD in young women. The findings were categorized by region, nation, and sociodemographic index.
dc.description.abstractRESULTS: The highest age-standardized prevalence rates were observed in AUD (895.96 [95% uncertainty interval (UI) 722.6-1,103.58]), followed by AC (65.33 [95% UI 48.37-86.49]) and liver cancer from alcohol (0.13 [95% UI 0.09-0.19]) per 100,000 people. The highest age-standardized mortality rates were observed in AC (0.75 [95% UI 0.55-0.97]), followed by AUD (0.48 [95% UI 0.43-0.53]) and liver cancer from alcohol (0.06 [95% UI 0.04-0.09]). The highest burdens of AC and AUD were observed in Central Europe, whereas the high-income Asia Pacific had the highest burden of liver cancer from alcohol.
dc.description.abstractDISCUSSION: Throughout the past decade, the trend of AUD varied among regions while the impact of alcohol-associated liver disease has increased, requiring urgent public health strategy to mitigate these complications, particularly in female patients in Europe and the Asia-Pacific region.
dc.fuente.origenWOS
dc.identifier.doi10.14309/ajg.0000000000002642
dc.identifier.eissn1572-0241
dc.identifier.issn0002-9270
dc.identifier.urihttps://doi.org/10.14309/ajg.0000000000002642
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90269
dc.identifier.wosidWOS:001286731000018
dc.issue.numero5
dc.language.isoen
dc.pagina.final909
dc.pagina.inicio893
dc.revistaAmerican journal of gastroenterology
dc.rightsacceso restringido
dc.subjectalcohol
dc.subjectcirrhosis
dc.subjectliver cancer
dc.subjectwoman
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFrom Shadows to Spotlight: Exploring the Escalating Burden of Alcohol-Associated Liver Disease and Alcohol Use Disorder in Young Women
dc.typeartículo
dc.volumen119
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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