E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance

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dc.contributor.authorKoriyama, Chihaya
dc.contributor.authorAkiba, Suminori
dc.contributor.authorItoh, Tetsuhiko
dc.contributor.authorSueyoshi, Kazunobu
dc.contributor.authorMinakami, Yoshie
dc.contributor.authorCorvalan, Alejandro
dc.contributor.authorYonezawa, Suguru
dc.contributor.authorEizuru, Yoshito
dc.date.accessioned2024-01-10T12:05:03Z
dc.date.available2024-01-10T12:05:03Z
dc.date.issued2007
dc.description.abstractAIM: To examine the role of E-cadherin and betacatenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs).
dc.description.abstractMETHODS: We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients' prognosis and the expressions of these proteins.
dc.description.abstractRESULTS: Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of betacatenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 95% confidence interval (CI), 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequently in EBV-GCs than non-EBV-GCs (odds ratio = 2.23; 95% CI, 0.97-5.09), and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs (P = 0.024). Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis (P < 0.001). Among EBV-GCs, the depth of invasion (P = 0.005), lymph node metastasis (P = 0.004) and an intestinal type by Lauren classification (hazard ratio = 9.47; 95% CI, 2.67-33.6) were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC (hazard ratio = 0.32; 95% 0, 0.11-0.93).
dc.description.abstractCONCLUSION: We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV-GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions. (C) 2007 WJG. All rights reserved.
dc.fechaingreso.objetodigital2024-05-30
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3748/wjg.v13.i29.3925
dc.identifier.issn1007-9327
dc.identifier.pubmedidMEDLINE:17663505
dc.identifier.urihttps://doi.org/10.3748/wjg.v13.i29.3925
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75937
dc.identifier.wosidWOS:000248546500003
dc.information.autorucMedicina;Corvalán A;S/I;63885
dc.issue.numero29
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final3931
dc.pagina.inicio3925
dc.publisherW J G PRESS
dc.revistaWORLD JOURNAL OF GASTROENTEROLOGY
dc.rightsacceso restringido
dc.subjectEpstein-Barr virus
dc.subjectgastric carcinoma
dc.subjecte-cadherin
dc.subjectbeta-catenin
dc.subjectprognosis
dc.subjectEPITHELIAL-CELLS
dc.subjectHELICOBACTER-PYLORI
dc.subjectSIGNALING PATHWAYS
dc.subjectCYCLIN D1
dc.subjectC-MYC
dc.subjectPROTEIN
dc.subjectGENE
dc.subjectADENOCARCINOMAS
dc.subjectMETHYLATION
dc.subjectKINASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleE-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance
dc.typeartículo
dc.volumen13
sipa.codpersvinculados63885
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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