Defining a role for Interferon Epsilon in normal and complicated pregnancies

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dc.contributor.authorMiller, Derek
dc.contributor.authorRomero, Roberto
dc.contributor.authorKacerovsky, Marian
dc.contributor.authorMusilova, Ivana
dc.contributor.authorGalaz, Jose
dc.contributor.authorGarcia-Flores, Valeria
dc.contributor.authorXu, Yi
dc.contributor.authorPusod, Errile
dc.contributor.authorDemery-Poulos, Catherine
dc.contributor.authorGutierrez-Contreras, Pedro
dc.contributor.authorNing Liu, Tzu
dc.contributor.authorJung, Eunjung
dc.contributor.authorTheis, Kevin R.
dc.contributor.authorColeman, Lanetta A.
dc.contributor.authorGomez-Lopez, Nardhy
dc.date.accessioned2025-01-20T21:01:15Z
dc.date.available2025-01-20T21:01:15Z
dc.date.issued2022
dc.description.abstractInterferon epsilon (IFNe) is a recently described cytokine that is constitutively expressed in the female repro-ductive tract. However, the role of this hormonally regulated cytokine during human pregnancy is poorly un-derstood. Moreover, whether IFNe participates in host immune response against bacteria-driven intra-amniotic infection or cervical human papillomavirus infection during pregnancy is unknown. Herein, using a unique set of human samples derived from multiple study cohorts, we aimed to uncover the role of IFNe in normal and complicated pregnancies. We showed that IFNe is expressed in the myometrium, cervix, and chorioamniotic membranes, and may therefore represent a constitutive element of host defense mechanisms in these tissues during pregnancy. The expression of IFNe in the myometrium and cervix appeared greater in late gestation than in mid-pregnancy, but did not seem to be impacted by labor. Notably, concentrations of IFNe in amniotic fluid, but not cervical fluid, were increased in a subset of women undergoing spontaneous preterm labor with intra-amniotic infection, indicating that IFNe could participate in anti-microbial responses in the amniotic cavity. However, stimulation with Ureaplasma parvum and/or lipopolysaccharide did not enhance IFNE expression by amnion epithelial or cervical cells in vitro, implicating alternative sources of this cytokine during intra-amniotic or cervical infection, respectively. Collectively, our results represent the first characterization of IFNe expression by human reproductive and gestational tissues during normal pregnancy and suggest a role for this cytokine in intra-amniotic infection leading to preterm birth.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.heliyon.2022.e09952
dc.identifier.eissn2405-8440
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2022.e09952
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92843
dc.identifier.wosidWOS:000880784400021
dc.issue.numero7
dc.language.isoen
dc.revistaHeliyon
dc.rightsacceso restringido
dc.subjectAmniotic fluid
dc.subjectCervix
dc.subjectChorioamniotic membranes
dc.subjectIFNE
dc.subjectMyometrium
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleDefining a role for Interferon Epsilon in normal and complicated pregnancies
dc.typeartículo
dc.volumen8
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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