Results of Extremely-low-birth-weight Infants Randomized to Receive Extra Enteral Calcium Supply

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dc.contributor.authorCarroll, William F.
dc.contributor.authorFabres, Jorge
dc.contributor.authorNagy, Tim R.
dc.contributor.authorFrazier, Marcela
dc.contributor.authorRoane, Claire
dc.contributor.authorPohlandt, Frank
dc.contributor.authorCarlo, Waldemar A.
dc.contributor.authorThome, Ulrich H.
dc.date.accessioned2024-01-10T12:42:09Z
dc.date.available2024-01-10T12:42:09Z
dc.date.issued2011
dc.description.abstractBackground and Objective: Bone mineral deficiency continues to occur in extremely-low-birth-weight (ELBW) infants despite formulas enriched in calcium (Ca) and phosphorus (P). This study tested whether extra enteral Ca supplementation increases bone mineral content (BMC) and prevents dolichocephalic head flattening and myopia in ELBW infants.
dc.description.abstractStudy Design: Infants 401 to 1000 birth weight receiving enteral feeds were randomized to receive feeds supplemented with Ca-gluconate powder or pure standard feeds. The main outcome measures were the excretion of Ca and P by weekly spot urine measurements, the degree of dolichocephalic deformation (fronto-occipital diameter to biparietal diameter ratio, FOD/BPD) at 36 weeks postmenstrual age, and the BMC (by dual-energy x-ray absorptiometry) at discharge. Cycloplegic refraction was measured at 18 to 22 months corrected age.
dc.description.abstractPatients and Results: Ninety-nine ELBW infants with a gestational age of 26 weeks (23-31) (median [minimum-maximum]) were randomized at a postnatal age of 12 days (5-23) weighing 790 g (440-1700). Urinary Ca excretion increased and P excretion decreased in the Ca-supplemented group. Total BMC was 89.9 +/- 2.4 g (mean +/- SE) in the supplemented group and 85.2 +/- 2.6 g in the control group (P = 0.19). The FOD/BPD was 1.50 (1.13-1.69, mean +/- SD [standard deviation]) and 1.47 (1.18-1.64) in the supplemented and control groups, and the refraction 0.98 +/- 1.23 and 1.40 +/- 1.33 dpt (P = 0.68), respectively in 64 ELBW infants (79% of survivors) at 2-year follow-up.
dc.description.abstractConclusions: Extra enteral Ca supplementation did not change BMC, head shape, or refraction. The decreased P excretion may reflect P deficiency in infants receiving extra Ca, preventing improved bone mineral accretion.
dc.description.funderNIH
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/MPG.0b013e3182187ecd
dc.identifier.eissn1536-4801
dc.identifier.issn0277-2116
dc.identifier.pubmedidMEDLINE:21865980
dc.identifier.urihttps://doi.org/10.1097/MPG.0b013e3182187ecd
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77486
dc.identifier.wosidWOS:000294247000018
dc.information.autorucMedicina;Fabres J;S/I;71713
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final345
dc.pagina.inicio339
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
dc.rightsacceso restringido
dc.subjectbioavailability
dc.subjectbone mineral content
dc.subjectbone mineral density
dc.subjectphosphorus
dc.subjectpreterm infant
dc.subjectBONE-MINERAL CONTENT
dc.subjectEXTREMELY PRETERM INFANTS
dc.subjectGROWTH
dc.subjectPHOSPHORUS
dc.subjectBODY
dc.subjectMYOPIA
dc.subjectAGE
dc.subjectSUPPLEMENTATION
dc.subjectPREMATURITY
dc.subjectRETINOPATHY
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleResults of Extremely-low-birth-weight Infants Randomized to Receive Extra Enteral Calcium Supply
dc.typeartículo
dc.volumen53
sipa.codpersvinculados71713
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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