Estrategia de pesquisa sistemática y seguimiento prolongado revela alto número de nuevas infecciones tuberculosas en contactos adultos en la Región Metropolitana, Chile

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dc.catalogadorpva
dc.contributor.authorBalcells Marty, María Elvira
dc.contributor.authorCarvajal, Camila
dc.contributor.authorFernández, Paula
dc.contributor.authorRuiz-Tagle, Cinthya
dc.contributor.authorPizarro, Alejandra
dc.contributor.authorGarcía, Patricia
dc.contributor.authorPeña, Carlos
dc.contributor.authorCuevas, Gerardo
dc.contributor.authorNaves, Rodrigo
dc.date.accessioned2023-11-07T14:32:12Z
dc.date.available2023-11-07T14:32:12Z
dc.date.issued2020
dc.description.abstractBackground: Contact investigation is cardinal in the control of tuberculosis (TB) since it helps to stop its transmission. In Chile, the National TB Program strategy does not include latent TB infection testing, regular chemoprophylaxis or follow-up in adults. Active TB was found in only 1.2% of contacts at country-level during 2018. Aim: To evaluate the performance of a systematic screening ofadult household contacts with targeted chemoprophylaxis and prolonged active follow-up. Material and Methods: Prospective cohort of household contacts in Santiago. Two face-to-face visits (at 0 and 12 weeks) that included QuantiFERON TB-Gold plus tests (QFT), chest radiography (CXR) at 0 and 24 weeks and, periodic text messaging or phone call follow-up for up to 48 weeks were implemented. Contacts with positive QFT were referred for TB chemoprophylaxis. Results: A total of 200 contacts were enrolled, 69% were migrants. At baseline evaluation, 45% had a positive QFT result and 1.6% had co-prevalent active TB. At follow-up, 13% contacts further converted to QFT (+), and 5.1% more were diagnosed with active TB (mean follow-up time 32 weeks). Of these 10 further active TB cases, 6 (60%) had a negative QFT and all (100%) had normal CXR at baseline; while three cases occurred in QFT converters. Conclusions: In this cohort of household contacts, 6.7 % were diagnosed with active TB (more than 2/3 at follow-up) and 13% had a late QFT (+) conversion. Active and prolonged contacts’ follow-up are essential to detect new infections and tackle the TB epidemic in Chile.
dc.fechaingreso.objetodigital2023-11-07
dc.fuente.origenConveris
dc.identifier.doi10.4067/s0034-98872020000200151
dc.identifier.issn0034-9887
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85088884255
dc.identifier.urihttp://dx.doi.org/10.4067/s0034-98872020000200151
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75244
dc.information.autorucEscuela de Medicina; Balcells Marty, María Elvira; 0000-0002-7223-9665; 7462
dc.issue.numero2
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final159
dc.pagina.inicio151
dc.revistaRevista médica de Chilees_ES
dc.rightsacceso abierto
dc.subjectLatent tuberculosises_ES
dc.subjectContact tracinges_ES
dc.subjectTuberculosises_ES
dc.subjectTuberculosis, Pulmonaryes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleEstrategia de pesquisa sistemática y seguimiento prolongado revela alto número de nuevas infecciones tuberculosas en contactos adultos en la Región Metropolitana, Chilees_ES
dc.title.alternativeSystematic screening of adult household contacts of patients with active pulmonary tuberculosis reveals high rates of new infections during follow-upes_ES
dc.typeartículo
dc.volumen148
sipa.codpersvinculados7462
sipa.indexPubmed
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2023-11-06
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