Downregulated Th17 responses are associated with reduced gastritis in <i>Helicobacter pylori</i>-infected children

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dc.contributor.authorSerrano, C.
dc.contributor.authorWright, S. W.
dc.contributor.authorBimczok, D.
dc.contributor.authorShaffer, C. L.
dc.contributor.authorCover, T. L.
dc.contributor.authorVenegas, A.
dc.contributor.authorSalazar, M. G.
dc.contributor.authorSmythies, L. E.
dc.contributor.authorHarris, P. R.
dc.contributor.authorSmith, P. D.
dc.date.accessioned2025-01-24T00:08:57Z
dc.date.available2025-01-24T00:08:57Z
dc.date.issued2013
dc.description.abstractHelicobacter pylori induces less gastric inflammation in children than adults. Here we investigated whether this reduced inflammation involves dysregulated T helper type 17 (Th17) responses. H. pylori-infected children and adults in Santiago, Chile had similar levels of H. pylori colonization, proportions of bacteria containing cagA and s1/s2 vacA markers of virulence, and strain genotypes (predominantly hpEurope), but the children had significantly reduced levels of gastric inflammation and neutrophil infiltration. The reduced neutrophil accumulation in the infected children was accompanied by significantly fewer gastric Th17 cells and significantly lower levels of interleukin (IL)-17-specific mRNA and protein compared with the infected adults. The gastric mucosa of H. pylori-infected children also contained higher numbers of IL-10(+) cells and increased levels of both IL-10 and Foxp3 mRNA compared with that of the infected adults. Thus, reduced gastric inflammation, including diminished neutrophil accumulation, in H. pylori-infected children compared with infected adults is likely due to downregulated gastric Th17/IL-17 responses as a consequence of enhanced mucosal regulatory T-cell activity in the children.
dc.fuente.origenWOS
dc.identifier.doi10.1038/mi.2012.133
dc.identifier.eissn1935-3456
dc.identifier.issn1933-0219
dc.identifier.urihttps://doi.org/10.1038/mi.2012.133
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101975
dc.identifier.wosidWOS:000323331800009
dc.issue.numero5
dc.language.isoen
dc.pagina.final959
dc.pagina.inicio950
dc.revistaMucosal immunology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDownregulated Th17 responses are associated with reduced gastritis in <i>Helicobacter pylori</i>-infected children
dc.typeartículo
dc.volumen6
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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