Mild Traumatic Brain Injury Induces Mitochondrial Calcium Overload and Triggers the Upregulation of NCLX in the Hippocampus

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dc.catalogadorjlo
dc.contributor.authorMira, Rodrigo G.
dc.contributor.authorQuintanilla, Rodrigo A.
dc.contributor.authorCerpa Nebott, Waldo Francisco
dc.date.accessioned2024-01-29T17:48:29Z
dc.date.available2024-01-29T17:48:29Z
dc.date.issued2023
dc.description.abstractTraumatic brain injury (TBI) is brain damage due to external forces. Mild TBI (mTBI) is the most common form of TBI, and repeated mTBI is a risk factor for developing neurodegenerative diseases. Several mechanisms of neuronal damage have been described in the cortex and hippocampus, including mitochondrial dysfunction. However, up until now, there have been no studies evaluating mitochondrial calcium dynamics. Here, we evaluated mitochondrial calcium dynamics in an mTBI model in mice using isolated hippocampal mitochondria for biochemical studies. We observed that 24 h after mTBI, there is a decrease in mitochondrial membrane potential and an increase in basal matrix calcium levels. These findings are accompanied by increased mitochondrial calcium efflux and no changes in mitochondrial calcium uptake. We also observed an increase in NCLX protein levels and calcium retention capacity. Our results suggest that under mTBI, the hippocampal cells respond by incrementing NCLX levels to restore mitochondrial function.
dc.fechaingreso.objetodigital2024-05-09
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3390/antiox12020403
dc.identifier.issn2076-3921
dc.identifier.urihttps://doi.org/10.3390/antiox12020403
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81015
dc.identifier.wosidWOS:000938146600001
dc.information.autorucFacultad de Ciencias Biológicas; Mira Guzmán, Rodrigo Andrés; S/I; 215451
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott, Waldo Francisco; 0000-0001-7344-0144; 16584
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final16
dc.pagina.inicio1
dc.revistaAntioxidants
dc.rightsacceso abierto
dc.subjectTraumatic brain injury
dc.subjectMitochondrial calcium
dc.subject NCLX
dc.subject Hippocampus
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMild Traumatic Brain Injury Induces Mitochondrial Calcium Overload and Triggers the Upregulation of NCLX in the Hippocampus
dc.typeartículo
dc.volumen12
sipa.codpersvinculados215451
sipa.codpersvinculados16584
sipa.trazabilidadORCID;2024-01-15
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