New paradigms in acute viral bronchiolitis: Is it time to change our approach?

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dc.catalogadordfo
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorAstudillo Paredes, Patricio Andrés
dc.contributor.authorPuranik , Sandeep
dc.contributor.authorBrown, Mark A.
dc.contributor.authorCustovic, Adnan
dc.contributor.authorForno, Erick
dc.date.accessioned2025-03-20T18:25:45Z
dc.date.available2025-03-20T18:25:45Z
dc.date.issued2024
dc.description.abstractViral bronchiolitis is the most common pediatric acute respiratory infection leading to hospitalization, and it causes a significant healthcare burden worldwide. Current guidelines recommend supportive management after many clinical trials on specific therapies failed to demonstrate benefits. However, several studies in the past decade have revealed that bronchiolitis may not be a homogeneous disease, but instead may constitute an umbrella comprised of different “endotypes” and “phenotypes” based on patient characteristics, etiology, pathophysiological mechanisms, and clinical presentation. In this extensive review, we summarize the current evidence that several different types of bronchiolitis (“bronchiolitides”) coexist, with different short- and long-term consequences on respiratory health and the risk of asthma development. Disease pathobiology, immune response, and clinical characteristics may differ between the two most prevalent viral agents, respiratory syncytial virus and rhinovirus. Recent randomized trials have shown that some subgroups of children may benefit from the use of systemic corticosteroids and/or bronchodilators. These findings also suggest that some children may benefit from individualized therapeutical approaches for viral bronchiolitis rather than following broad recommendations for treating all patients uniformly using only supportive management.
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.prrv.2024.10.004
dc.identifier.issn1526-0542
dc.identifier.scopusidSCOPUS_ID:85210088867
dc.identifier.urihttps://doi.org/10.1016/j.prrv.2024.10.004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102886
dc.information.autorucEscuela de Medicina; Castro Rodriguez Jose Antonio; 0000-0002-0708-4281; 113247
dc.information.autorucEscuela de Medicina; Astudillo Paredes Patricio Andres; S/I; 179203
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaPaediatric Respiratory Reviews
dc.rightsacceso restringido
dc.subjectAcute viral bronchiolitis
dc.subjectAsthma
dc.subjectPhenotypes
dc.subjectRecurrent wheezing
dc.subjectRespiratory syncytial virus
dc.subjectRhinovirus
dc.subjectViral infection
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNew paradigms in acute viral bronchiolitis: Is it time to change our approach?
dc.typeartículo de revisión
sipa.codpersvinculados113247
sipa.codpersvinculados179203
sipa.trazabilidadSCOPUS;2024-12-08
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