Neurodevelopmental follow-up of children born to mothers with Graves’ disease and neonatal hyperthyroidism

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dc.catalogadordfo
dc.contributor.authorGrob Lunecke, Francisca Andrea
dc.contributor.authorBrown, Amy
dc.contributor.authorZacharin, Margaret
dc.date.accessioned2024-05-13T15:20:22Z
dc.date.available2024-05-13T15:20:22Z
dc.date.issued2024
dc.description.abstractIntroduction: Neonatal hyperthyroidism, often caused by maternal Graves' disease (GD), carries potential neurodevelopmental risks for children. Excessive thyroid hormones during fetal development are linked to neurological issues like ADHD and epilepsy. However, the impact of transient neonatal hyperthyroidism is not well understood. Methods: In a retrospective study at the Royal Children's Hospital in Melbourne, 21 neonates with hyperthyroidism from mothers with GD were examined. Of these, the parents of 10 children consented to participate; thus, questionnaires assessing executive functions, behavior, and social communication were completed. The outcomes were compared to those of control subjects recruited from the community using standardized tools (BRIEF, SDQ, SCQ). The results were analyzed against socio-demographic factors, maternal, and neonatal health. Results: No significant demographic or clinical differences were found between study participants (n=10) and nonparticipants (n=11). Participants, compared to controls, showed similar family demographics but a higher proportion of control parents had university-level education (p=0.003). Patients displayed more social (SCQ scores: 12.1±2.5 vs. 6±1.07, p=0.008) and behavioral difficulties (SDQ scores: 10.2±2.17 vs. 6.14±1.03, p=0.03), with increased executive function challenges (BRIEF scores indicating problem-solving and self-regulation difficulties). Significant effects of family living situation and partner education level on neurodevelopmental measures were noted, underscoring the influence of socio-demographic factors. Conclusions: These findings suggest neonatal hyperthyroidism might lead to subtle neurodevelopmental variations, with socio-economic elements and family dynamics possibly intensifying these effects. While most children didn't show severe impairments, early detection and intervention are recommended. The research emphasizes the necessity for inclusive care approaches that consider socio-economic factors for children affected by neonatal hyperthyroidism
dc.fechaingreso.objetodigital2024-05-13
dc.fuente.origenORCID
dc.identifier.doi10.1159/000539268
dc.identifier.eissn1663-2826
dc.identifier.issn1663-2818
dc.identifier.urihttps://doi.org/10.1159/000539268
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85565
dc.identifier.wosidWOS:001252977100001
dc.information.autorucEscuela de Medicina; Grob Lunecke Francisca Andrea; 0000-0001-7685-9311; 209562
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.revistaHormone research in paediatrcs
dc.rightsacceso abierto
dc.rights.licenseAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.es
dc.subjectNeonatal hyperthyroidism
dc.subjectGraves' disease
dc.subjectNeurodevelopment
dc.subjectExecutive functioning
dc.subjectBehavior
dc.subjectSocioeconomic factors
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.ods04 Quality education
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa04 Educación de calidad
dc.titleNeurodevelopmental follow-up of children born to mothers with Graves’ disease and neonatal hyperthyroidism
dc.typeartículo
sipa.codpersvinculados209562
sipa.trazabilidadORCID;2024-05-13
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