Mechanical Roles of Vinculin/β-catenin interaction in Adherens Junction

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dc.catalogadorjca
dc.contributor.authorBertocchi , Cristina
dc.contributor.authorRavasio, Andrea
dc.contributor.authorOng, Hui Ting
dc.contributor.authorToyama, Yusuke
dc.contributor.authorKanchanawong, Pakorn
dc.date.accessioned2024-02-27T16:02:49Z
dc.date.available2024-02-27T16:02:49Z
dc.date.issued2019
dc.description.abstractMechanical force transmission through the adherens junctions (AJs) are highly regulated processes essential for multicellular organization of tissues. AJ proteins such as E-cadherin, α-catenin, and vinculin have been shown to be sensing or bearing mechanical forces being transmitted between the actin cytoskeleton and the intercellular contacts. However, the molecular organization and connectivity of these components remains not well understood. Using a super-resolution microscopy approach, we report that vinculin, once activated, could form a direct structural connection with β-catenin, which can bypass α-catenin, one of the main mechanotransducers in AJs. Direct vinculin/β-catenin interaction is capable of supporting mechanical tension and contributes to the stabilization of the cadherin-catenin complexes. These findings suggest a multi-step model for the force-dependent reinforcement of AJs whereby α-catenin may serve as the initial catalytic activator of vinculin, followed by vinculin translocation to form a direct link between E-cadherin-bound β-catenin and the actin cytoskeleton
dc.fuente.origenORCID
dc.identifier.doi10.1101/770735
dc.identifier.urihttps://doi.org/10.1101/770735
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81358
dc.information.autorucFacultad de Ciencias Biológicas; Bertocchi , Cristina; 0000-0003-0907-1318; 1078032
dc.information.autorucInstituto de Ingeniería Biológica y Médica;Ravasio, Andrea;S/I;1071356
dc.language.isoes
dc.nota.accesoContenido parcial
dc.rightsacceso restringido
dc.subjectVinculin
dc.subjectβ-catenin
dc.subjectα-catenin
dc.subjectAdherens junctions
dc.subjectMechanotransduction
dc.subjectSuper-29 resolution microscopy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleMechanical Roles of Vinculin/β-catenin interaction in Adherens Junction
dc.typepreprint
sipa.codpersvinculados1078032
sipa.codpersvinculados1071356
sipa.trazabilidadORCID;2024-01-15
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