Ability of a Combined FIB4/miRNA181a Score to Predict Significant Liver Fibrosis in NAFLD Patients

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dc.contributor.authorLima, Rodrigo Vieira Costa
dc.contributor.authorStefano, Jose Tadeu
dc.contributor.authorMalta, Fernanda de Mello
dc.contributor.authorPinho, Joao Renato Rebello
dc.contributor.authorCarrilho, Flair Jose
dc.contributor.authorArrese, Marco
dc.contributor.authorOliveira, Claudia P.
dc.date.accessioned2025-01-20T22:03:23Z
dc.date.available2025-01-20T22:03:23Z
dc.date.issued2021
dc.description.abstractLiver biopsy is the gold standard for assessing fibrosis, but there is a need to seek non-invasive biomarkers for this purpose. The aim of this study was to evaluate the correlation between the serum levels of the microRNAs miR-21, miR-29a, miR-122, miR-155 and miR-181a and the phenotypic expression of NAFLD. A cross-sectional study was carried out on 108 NAFLD patients diagnosed by liver biopsy. FIB-4 and NAFLD fibrosis scores were calculated. The comparison between the distributions of microRNA values according to the presence or absence of histological fibrosis (F2-F4) was performed. A multivariate logistic regression analysis was performed to build a score for predicting fibrosis using FIB-4 and Ln (miR-181a) as independent variables. Only miR-181a showed a statistical difference between patients with significant liver fibrosis (>F2) and those without (F0-F1) (p = 0.017). FIB-4 revealed an AUC on the ROC curve of 0.667 to predict clinically significant fibrosis (F2-F4). When assessed using the score in association with Ln (miR-181a), there was an improvement in the ROC curve, with an AUC of 0.71. miR-181a can be used as a non-invasive method of predicting fibrosis in NAFLD, and an association with FIB-4 has the potential to increase the accuracy of each method alone.
dc.fuente.origenWOS
dc.identifier.doi10.3390/biomedicines9121751
dc.identifier.eissn2227-9059
dc.identifier.urihttps://doi.org/10.3390/biomedicines9121751
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94036
dc.identifier.wosidWOS:000736296900001
dc.issue.numero12
dc.language.isoen
dc.revistaBiomedicines
dc.rightsacceso restringido
dc.subjectnon-alcoholic fatty liver disease
dc.subjectnonalcoholic steatohepatitis
dc.subjectmicroRNAs
dc.subjectmiR-181a
dc.subjectliver fibrosis
dc.subjectFIB-4
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAbility of a Combined FIB4/miRNA181a Score to Predict Significant Liver Fibrosis in NAFLD Patients
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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