Identification of 3 novel herpesviruses in prosimians with lymphoproliferative disease

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dc.contributor.authorKunze, Patricia E.
dc.contributor.authorCortes-Hinojosa, Galaxia
dc.contributor.authorWilliams, Cathy V.
dc.contributor.authorArcher, Linda L.
dc.contributor.authorFerrante, Jason A.
dc.contributor.authorWellehan, James F. X., Jr.
dc.date.accessioned2025-01-20T20:09:35Z
dc.date.available2025-01-20T20:09:35Z
dc.date.issued2023
dc.description.abstractAlthough many studies have characterized catarrhine and platyrrhine primate herpesviruses, little is known about herpesviruses in prosimians. We aimed to identify and characterize herpesviruses in prosimians with proliferative lymphocytic disease. DNA was extracted from tissues of 9 gray mouse lemurs (Microcebus murinus) and 3 pygmy slow lorises (Nycticebus pygmaeus) with lymphoproliferative lesions, and we performed nested PCR and sequencing for detection of herpesviruses and polyomaviruses. We identified 3 novel herpesviruses and performed phylogenetic analyses to characterize their relationship with other herpesviruses. A gray mouse lemur herpesvirus clustered with other primate herpesviruses within the subfamily Betaherpesvirinae, just basal to the genus Cytomegalovirus. The other gray mouse lemur herpesvirus and the pygmy slow loris herpesvirus clustered within the subfamily Gammaherpesvirinae, although the relationships within the subfamily were less resolved. Quantitative PCR assays were developed for the 2 new gray mouse lemur viruses, providing specific, faster, less expensive, and quantitative detection tools. Further studies are needed to elucidate the relationship between the presence of these viruses and the severity or presence of lymphoproliferative lesions in prosimians.
dc.fuente.origenWOS
dc.identifier.doi10.1177/10406387231183431
dc.identifier.eissn1943-4936
dc.identifier.issn1040-6387
dc.identifier.urihttps://doi.org/10.1177/10406387231183431
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92011
dc.identifier.wosidWOS:001016140300001
dc.language.isoen
dc.revistaJournal of veterinary diagnostic investigation
dc.rightsacceso restringido
dc.subjectCheirogaleidae
dc.subjectLorisidae
dc.subjectlymphoproliferative disorders
dc.subjectOrthoherpesviridae
dc.subjectPCR
dc.subjectprosimians
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIdentification of 3 novel herpesviruses in prosimians with lymphoproliferative disease
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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