Balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension

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dc.contributor.authorSepulveda, Pablo
dc.contributor.authorOrtega, Juan
dc.contributor.authorArmijo, German
dc.contributor.authorTorres, Jose
dc.contributor.authorRamirez, Pablo
dc.contributor.authorBackhouse, Christian
dc.contributor.authorVargas, Cesar
dc.contributor.authorLopez, Leonel
dc.contributor.authorGonzalez, Felipe
dc.contributor.authorPuentes, Angel
dc.contributor.authorDonoso, Hernan
dc.contributor.authorBellet, Augusto
dc.contributor.authorGodoy, Diego
dc.contributor.authorAraya, Mario
dc.contributor.authorLuz Andrade, Carmen
dc.contributor.authorPablo Molina, Juan
dc.contributor.authorNazzal, Carolina
dc.date.accessioned2024-01-10T13:44:17Z
dc.date.available2024-01-10T13:44:17Z
dc.date.issued2019
dc.description.abstractBackground: Balloon pulmonary angioplasty (BPA) is a therapeutic alternative for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Aim: To report the initial experience with the "refined BPA technique" with the use of intravascular images. Patients and Methods: Between June 2015 and June 2016 we selected fourteen patients with CTEPH who were considered candidates for BPA. Lesions targeted for treatment were further analyzed using intravascular imaging with optical frequency domain imaging (OFDI). We report the immediate hemodynamic results and four weeks of follow-up of the first eight patients of this series. Results: We performed 16 BPA in eight patients aged 61 +/- 14 years (88% women). Mean pulmonary artery pressure (PAPm) was 48.6 +/- 5.8 mmHg. Success was achieved in seven patients (88%). A mean of 2.3 segments per patient were intervened in 11 sessions (1.6 sessions/patient). Only one patient developed lung reperfusion injury. No mortality was associated with the procedure. After the last BPA session, PAPm decreased to 37.4 +/- 8.6 mmHg (p=0.02). Pulmonary vascular resistance (RVP) decreased from 858,6 +/- 377,0 at baseline to 516,6 +/- 323,3 Dynes/sec/cm(-5) (p<0.01) and the cardiac index increased from 2.4 +/- 0.6 at baseline to 2.8 +/- 0.3 L/min/m(2) (p=0.01). At 4 weeks after the last BPA, WHO functional class improved from 3.3 +/- 0.5 to 2.5 +/- 0.5 (p<0,01) and six minutes walking distance from 331 +/- 92 to 451 +/- 149 m (p=0.01). Conclusions: BPA guided by OFDI for the treatment of inoperable CTEPH patients is a safe alternative with excellent immediate hemodynamic and clinical results.
dc.fechaingreso.objetodigital2024-05-29
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872019000400426
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:31344203
dc.identifier.urihttps://doi.org/10.4067/S0034-98872019000400426
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78882
dc.identifier.wosidWOS:000472530400004
dc.information.autorucFacultad de Medicina; Sepulveda Varela, Pablo Andres; S/I; 1095919
dc.issue.numero4
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final436
dc.pagina.inicio426
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso abierto
dc.subjectAngioplasty
dc.subjectHypertension
dc.subjectPulmonary
dc.subjectPulmonary Embolism
dc.subjectPERFUSION SCINTIGRAPHY
dc.subjectARTERIAL-HYPERTENSION
dc.subjectINOPERABLE PATIENTS
dc.subjectENDARTERECTOMY
dc.subjectEXPERIENCE
dc.subjectDIAGNOSIS
dc.subjectHEMODYNAMICS
dc.subjectPROGNOSIS
dc.subjectCT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBalloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension
dc.typeartículo
dc.volumen147
sipa.codpersvinculados1095919
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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