Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)

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dc.contributor.authorIbanez, Agustin
dc.contributor.authorUrquina, Hugo
dc.contributor.authorPetroni, Agustin
dc.contributor.authorBaez, Sandra
dc.contributor.authorLopez, Vladimir
dc.contributor.authordo Nascimento, Micaela
dc.contributor.authorHerrera, Eduar
dc.contributor.authorGuex, Raphael
dc.contributor.authorHurtado, Esteban
dc.contributor.authorBlenkmann, Alejandro
dc.contributor.authorBeltrachini, Leandro
dc.contributor.authorGelormini, Carlos
dc.contributor.authorSigman, Mariano
dc.contributor.authorLischinsky, Alicia
dc.contributor.authorTorralva, Teresa
dc.contributor.authorTorrente, Fernando
dc.contributor.authorCetkovich, Marcelo
dc.contributor.authorManes, Facundo
dc.date.accessioned2025-01-20T23:56:37Z
dc.date.available2025-01-20T23:56:37Z
dc.date.issued2012
dc.description.abstractBackground: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing.
dc.description.abstractMethodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face. word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind).
dc.description.abstractConclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0046877
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0046877
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95166
dc.identifier.wosidWOS:000309831500097
dc.issue.numero10
dc.language.isoen
dc.revistaPlos one
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNeural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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