Does a perturbation in visfatin homeostasis participate in the phenotype definition of preeclampsia and SGA?

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dc.catalogadorpau
dc.contributor.authorKim, Sun Kwon
dc.contributor.authorRomero, Roberto
dc.contributor.authorMazaki-Tovi, Shali
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorVaisbuch, Edi
dc.contributor.authorErez, Offer
dc.contributor.authorThan, Nandor
dc.contributor.authorGotsch, Francesca
dc.contributor.authorNhan-Chang, Chia-Ling
dc.contributor.authorChiaworapongsa, Tinnakorn
dc.contributor.authorGómez Mora, Ricardo Alberto
dc.contributor.authorMittal, Pooja
dc.contributor.authorHassan, Sonia
dc.contributor.authorPacora, Percy
dc.contributor.authorYeo, Lami
dc.date.accessioned2023-05-18T19:49:45Z
dc.date.available2023-05-18T19:49:45Z
dc.date.issued2009
dc.description.abstractObjective: Women with preeclampsia (PE) and those who delivered a small for gestational age (SGA) neonate share several mechanisms of disease including: chronic uteroplacental ischemia and failure of physiologic transformation of the spiral arteries. However, the clinical manifestation of these obstetrical syndromes is remarkably different. It has been proposed that an altered maternal metabolic state, as well as a unique circulating cytokines milieu, predispose women to develop either PE or SGA (Ness&Sibai AJOG 2006;195:40). Compelling evidence suggests that adipose tissue orchestrates both metabolic pathways and immunological responses via the production of adipokines. Visfatin is a novel adipocytokine with metabolic and immunomodulating properties. The objective of this study was to determine whether PE and SGA are associated with alterations in maternal circulating visfatin concentrations. Methods: This cross-sectional study included 255 pregnant women in the following groups: 1) normal pregnancy (n = 158); 2) patients with PE (n = 43) of which 32 had an AGA and 11 had an SGA neonate; and 3) patients who delivered an SGA neonate without PE (n = 54). Maternal plasma visfatin concentrations were measured by ELISA. Non-parametric tests and multiple linear regression analysis were used. Results: 1) Women who delivered an SGA neonate had higher median maternal plasma visfatin concentration than those with normal pregnancy (median: 20.0ng/ml, interquartile range: 17.2–24.6 vs. 15.2 ng/ml, 12.1–19.2, respectively; p. Conclusion: 1) Mothers with SGA, but not with PE, had a higher maternal plasma visfatin concentration than those with a normal pregnancy; 2) This finding suggests differential involvement of adipokines in SGA and PE; 3) We propose that perturbation of adipokine homeostasis may be implicated in the phenotypic definition and distinction of PE and SGA
dc.format.extent1 página
dc.fuente.origenORCID
dc.identifier.doi10.1080/10253890802519881
dc.identifier.issn1064-1955
dc.identifier.urihttps://doi.org/10.1080/10253890802519881
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/10253890802519881
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67112
dc.information.autorucEscuela de Medicina ; Gómez Mora, Ricardo Alberto ; 0000-0001-9267-304X ; 80926
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final463
dc.pagina.inicio463
dc.relation.ispartofWorld Congress International Society for the Study of Hypertension in Pregnancy (ISSHP) (16° ; 2009)
dc.revistaHypertension in Pregnancy
dc.rightsacceso restringido
dc.titleDoes a perturbation in visfatin homeostasis participate in the phenotype definition of preeclampsia and SGA?
dc.typecomunicación de congreso
dc.volumen27
sipa.codpersvinculados80926
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