Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish

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dc.article.number4942
dc.catalogadorgrr
dc.contributor.authorGarcia-Lopez, Juan P.
dc.contributor.authorGrimaldi, Alexandre
dc.contributor.authorChen, Zelin
dc.contributor.authorMeneses Araya, Claudio Antonio
dc.contributor.authorBravo-Tello, Karina
dc.contributor.authorBresciani, Erica
dc.contributor.authorBanderas, Alvaro
dc.contributor.authorBurgess, Shawn M.
dc.contributor.authorHernandez, Pedro P.
dc.contributor.authorFeijoo, Carmen G.
dc.date.accessioned2023-11-22T19:21:41Z
dc.date.available2023-11-22T19:21:41Z
dc.date.issued2023
dc.description.abstractNeutrophil ontogeny in zebrafish may be a continuum or consist of distinct lineages. Here the authors characterise neutrophils derived from rostral blood island and caudal haematopoietic tissue lineages and show differential gene expression and function in steady state and during wound healing., The current view of hematopoiesis considers leukocytes on a continuum with distinct developmental origins, and which exert non-overlapping functions. However, there is less known about the function and phenotype of ontogenetically distinct neutrophil populations. In this work, using a photoconvertible transgenic zebrafish line; Tg(mpx:Dendra2), we selectively label rostral blood island-derived and caudal hematopoietic tissue-derived neutrophils in vivo during steady state or upon injury. By comparing the migratory properties and single-cell expression profiles of both neutrophil populations at steady state we show that rostral neutrophils show higher csf3b expression and migration capacity than caudal neutrophils. Upon injury, both populations share a core transcriptional profile as well as subset-specific transcriptional signatures. Accordingly, both rostral and caudal neutrophils are recruited to the wound independently of their distance to the injury. While rostral neutrophils respond uniformly, caudal neutrophils respond heterogeneously. Collectively, our results reveal that co-existing neutrophils populations with ontogenically distinct origin display functional differences.
dc.fechaingreso.objetodigital2023-11-22
dc.format.extent15 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41467-023-40662-7
dc.identifier.eissn2041-1723
dc.identifier.scopusidSCOPUS_ID: 85168061227
dc.identifier.urihttps://doi.org/10.1038/s41467-023-40662-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75401
dc.identifier.wosidWOS:001051523700014
dc.information.autorucFacultad de Agronomía e Ingenieria Forestal; Meneses Araya, Claudio Antonio; 0000-0002-6452-8950; 1246418
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherNature Portfolio
dc.revistaNature Communications
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOntogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish
dc.typeartículo
dc.volumen14
sipa.codpersvinculados1246418
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