Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank

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dc.contributor.authorMathioudakis, Alexander G.
dc.contributor.authorMiligkos, Michael
dc.contributor.authorBoccabella, Cristina
dc.contributor.authorAlimani, Gioulinta S.
dc.contributor.authorCustovic, Adnan
dc.contributor.authorDeschildre, A.
dc.contributor.authorDucharme, Francine Monique
dc.contributor.authorKalayci, Omer
dc.contributor.authorMurray, Clare
dc.contributor.authorGarcia, Antonio Nieto
dc.contributor.authorPhipatanakul, Wanda
dc.contributor.authorPrice, David
dc.contributor.authorSheikh, Aziz
dc.contributor.authorAgache, Ioana Octavia
dc.contributor.authorBacharier, Leonard
dc.contributor.authorBeloukas, Apostolos
dc.contributor.authorBentley, Andrew
dc.contributor.authorBonini, Matteo
dc.contributor.authorCastro-Rodriguez, Jose A.
dc.contributor.authorDe Carlo, Giuseppe
dc.contributor.authorCraig, Timothy
dc.contributor.authorDiamant, Zuzana
dc.contributor.authorFeleszko, Wojciech
dc.contributor.authorFelton, Tim
dc.contributor.authorGern, James E.
dc.contributor.authorGrigg, Jonathan
dc.contributor.authorHedlin, Gunilla
dc.contributor.authorHossny, Elham M.
dc.contributor.authorIerodiakonou, Despo
dc.contributor.authorJartti, Tuomas
dc.contributor.authorKaplan, Alan
dc.contributor.authorLemanske, Robert F.
dc.contributor.authorLe Souef, Peter N.
dc.contributor.authorMakela, Mika J.
dc.contributor.authorMathioudakis, Georgios A.
dc.contributor.authorMatricardi, Paolo
dc.contributor.authorMitrogiorgou, Marina
dc.contributor.authorMorais-Almeida, Mario
dc.contributor.authorNagaraju, Karthik
dc.contributor.authorPapageorgiou, Effie
dc.contributor.authorPite, Helena
dc.contributor.authorPitrez, Paulo M. C.
dc.contributor.authorPohunek, Petr
dc.contributor.authorRoberts, Graham
dc.contributor.authorTsiligianni, Ioanna
dc.contributor.authorTurner, Stephen
dc.contributor.authorVijverberg, Susanne
dc.contributor.authorWinders, Tonya A.
dc.contributor.authorWong, Gary W. K.
dc.contributor.authorXepapadaki, Paraskevi
dc.contributor.authorZar, Heather J.
dc.contributor.authorPapadopoulos, Nikolaos G.
dc.date.accessioned2025-01-20T22:09:32Z
dc.date.available2025-01-20T22:09:32Z
dc.date.issued2021
dc.description.abstractIntroduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted. Methods and analysis Standard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively. Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence. Ethics and dissemination Ethics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank. PROSPERO registration numbers CRD42020132990, CRD42020171624.
dc.fuente.origenWOS
dc.identifier.doi10.1136/bmjopen-2020-048338
dc.identifier.issn2044-6055
dc.identifier.urihttps://doi.org/10.1136/bmjopen-2020-048338
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94335
dc.identifier.wosidWOS:000691603500023
dc.issue.numero7
dc.language.isoen
dc.revistaBmj open
dc.rightsacceso restringido
dc.subjectpaediatrics
dc.subjectasthma
dc.subjectpaediatric thoracic medicine
dc.subjectthoracic medicine
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleManagement of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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