Proinflammatory cytokine expression in gastric tissue from children with Helicobacter pylori-associated gastritis

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dc.contributor.authorGuiraldes, E
dc.contributor.authorDuarte, I
dc.contributor.authorPena, A
dc.contributor.authorGodoy, A
dc.contributor.authorEspinosa, MN
dc.contributor.authorBravo, R
dc.contributor.authorLarrain, F
dc.contributor.authorSchultz, M
dc.contributor.authorHarris, P
dc.date.accessioned2024-01-10T13:16:44Z
dc.date.available2024-01-10T13:16:44Z
dc.date.issued2001
dc.description.abstractBackground: Helicobacter pylori infection of the gastric mucosa in humans is usually acquired early in life. The chronic inflammation that ensues involves the increased production of inflammatory cytokines. Published data on production of these mediators by gastric mucosa of H. pylori-infected children are few.
dc.description.abstractMethods: Seventy-nine children, aged 5 to 18 years, referred for upper gastrointestinal endoscopy to four separate hospitals in Chile, were studied. The concentrations of interleukin (IL)-1 beta, IL-6, IL-8, and tumor necrosis factor a were measured in homogenates of gastric mucosal biopsy specimens. Cytokine expression was confirmed by reverse transcription polymerase chain reaction. These data were correlated with the patients' clinical, histologic and sociodemographic status.
dc.description.abstractResults: Patient rate of colonization by H. pylori was inversely correlated with socioeconomic status (P < 0.005) and positively correlated with age (P < 0.0025). In gastric mucosa, concentrations of IL-1 beta, IL-8, and tumor necrosis factor a were all significantly higher in H. pylori-positive patients than in H. pylori-negative patients and in patients who had histologic gastritis than in those with normal gastric mucosa. In patients with peptic ulcer disease, only IL-1 beta and IL-8 concentrations were significantly elevated when compared with those of patients without ulcers. Interleukin-6 concentrations were comparable among the different groups analyzed.
dc.description.abstractConclusions: This study suggests that increased gastric mucosal production of the proinflammatory cytokines IL-1 beta and IL-8 is probably involved in H. pylori-associated gastric damage in children and may be crucial in determining the different clinical outcomes.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00005176-200108000-00006
dc.identifier.eissn1536-4801
dc.identifier.issn0277-2116
dc.identifier.pubmedidMEDLINE:11568511
dc.identifier.urihttps://doi.org/10.1097/00005176-200108000-00006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78608
dc.identifier.wosidWOS:000170755800006
dc.information.autorucMedicina;Guiraldes E;S/I;98921
dc.information.autorucMedicina;Harris P;S/I;80706
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final132
dc.pagina.inicio127
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
dc.rightsacceso restringido
dc.subjectHelicobacter pylori
dc.subjectcytokines
dc.subjectgastritis
dc.subjectchildren
dc.subjectpeptic ulcer
dc.subjectTUMOR-NECROSIS-FACTOR
dc.subjectSURFACE-PROTEINS
dc.subjectFACTOR-ALPHA
dc.subjectMACROPHAGES
dc.subjectINFECTION
dc.subjectRNA
dc.subjectINTERLEUKIN-8
dc.subjectEPIDEMIOLOGY
dc.subjectIMMUNITY
dc.subjectUREASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleProinflammatory cytokine expression in gastric tissue from children with Helicobacter pylori-associated gastritis
dc.typeartículo
dc.volumen33
sipa.codpersvinculados98921
sipa.codpersvinculados80706
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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